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Protein

Isocitrate dehydrogenase kinase/phosphatase

Gene

aceK

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.UniRule annotation

Catalytic activityi

ATP + [isocitrate dehydrogenase (NADP+)] = ADP + [isocitrate dehydrogenase (NADP+)] phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei346 – 3461ATPUniRule annotation
Active sitei381 – 3811UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi325 – 3317ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Kinase, Protein phosphatase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACIT397945:GI5W-4416-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase kinase/phosphataseUniRule annotation (EC:2.7.11.5UniRule annotation, EC:3.1.3.-UniRule annotation)
Short name:
IDH kinase/phosphataseUniRule annotation
Short name:
IDHK/PUniRule annotation
Gene namesi
Name:aceKUniRule annotation
Ordered Locus Names:Aave_4369
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000002596 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Isocitrate dehydrogenase kinase/phosphatasePRO_0000288277Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi397945.Aave_4369.

Family & Domainsi

Sequence similaritiesi

Belongs to the AceK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VS7. Bacteria.
COG4579. LUCA.
HOGENOMiHOG000247673.
KOiK00906.
OrthoDBiEOG6HQSJX.

Family and domain databases

HAMAPiMF_00747. AceK.
InterProiIPR010452. Isocitrate_DH_AceK.
[Graphical view]
PfamiPF06315. AceK. 1 hit.
[Graphical view]
PIRSFiPIRSF000719. AceK. 1 hit.
ProDomiPD043552. Isocitrate_DH_AceK. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A1TVC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPRRLDSPA AYGIAQAMMD GFDRHYRLFR AESARAKHRF ETSDWSGQQR
60 70 80 90 100
AQRERIEFYD LRVKECVRRL EKEFSAGAQP MDVWHQVKLH YIGLLVGHRQ
110 120 130 140 150
PELAETFFNS VTTKILHRTH FHNDFIFVRP AISTEYLEND EPGARPTYRA
160 170 180 190 200
YYPTPESLQE TLVRVVDNFQ LQGEFEDLAR DAGRVAEVMR PRLGPAKWRA
210 220 230 240 250
NFQIQVLSSL FYRNKGAYLV GKVINGFQEL AFALPILHGT DGRYVIDAAL
260 270 280 290 300
FGEDDLQMLF SFARAYFMVD MEIPSAYVQF LRSLMPRKPR AELYNALGLA
310 320 330 340 350
KQGKTLFYRD FLHHLRYSSD RFRIAPGIKG MVMLVFDLPS FPFVFKVIKD
360 370 380 390 400
YYPPQKDTTR EQIKGKYLLV KQHDRVGRMA DTLEYSEVAF PRERFEDDLI
410 420 430 440 450
AEIEKFAPSQ LEISDRDGDG NVEVILKHVY IERRMIPLNI YLQEAFDAGP
460 470 480 490 500
HDARARQQME RSVVEYGNAI KDLVAANIFP GDMLWKNFGV TRNGKVVFYD
510 520 530 540 550
YDEIEYLTDC HFRRVPAPRN EEDELSGEVW WAVGPRDVFP ETFGPFLLGN
560 570 580 590 600
DAVREVFMRH HADLLDPVFW QSHKERIQAG HMYDVFPYDP ERRFGAGTGS

PA
Length:602
Mass (Da):70,101
Last modified:February 6, 2007 - v1
Checksum:i745D93F92FD561D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA. Translation: ABM34909.1.
RefSeqiWP_011797380.1. NC_008752.1.

Genome annotation databases

EnsemblBacteriaiABM34909; ABM34909; Aave_4369.
KEGGiaav:Aave_4369.
PATRICi20683957. VBIAciCit38535_4443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA. Translation: ABM34909.1.
RefSeqiWP_011797380.1. NC_008752.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi397945.Aave_4369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM34909; ABM34909; Aave_4369.
KEGGiaav:Aave_4369.
PATRICi20683957. VBIAciCit38535_4443.

Phylogenomic databases

eggNOGiENOG4105VS7. Bacteria.
COG4579. LUCA.
HOGENOMiHOG000247673.
KOiK00906.
OrthoDBiEOG6HQSJX.

Enzyme and pathway databases

BioCyciACIT397945:GI5W-4416-MONOMER.

Family and domain databases

HAMAPiMF_00747. AceK.
InterProiIPR010452. Isocitrate_DH_AceK.
[Graphical view]
PfamiPF06315. AceK. 1 hit.
[Graphical view]
PIRSFiPIRSF000719. AceK. 1 hit.
ProDomiPD043552. Isocitrate_DH_AceK. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AAC00-1.

Entry informationi

Entry nameiACEK_ACIAC
AccessioniPrimary (citable) accession number: A1TVC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.