A1TUP2 (ARGB_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Aave_4139

Organism

Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000010480
Regions
	Region	69 – 70	2	Substrate binding By similarity
Sites
	Binding site	91	1	Substrate By similarity
	Binding site	193	1	Substrate By similarity
	Site	34	1	Transition state stabilizer By similarity
	Site	253	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TUP2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 53BB4DB9DD4CF014	FASTA	296	31,505
	10 20 30 40 50 60 MTDLQSIAPR DKAEILAQAL PYIRKFHGKT IVIKYGGNAM TDPALQADFA EDVVLLKLVG 70 80 90 100 110 120 MNPVVVHGGG PQIETALKRL GKQGHFIQGM RVTDAETMEV VEWVLAGEVQ QDIVGLINQA 130 140 150 160 170 180 GGKAVGLTGR DGGLIRARKL KMVDKDDPSK EHDIGQVGDI VSIDPSVVKA LQDDAFIPVI 190 200 210 220 230 240 SPLGFGEENE SYNINADVVA SKLATVLKAE KLMMLTNIPG VLNKSGALIP ELTAREIDEL 250 260 270 280 290 VVDGTISGGM LPKIAGAIDA AKSGVNAVHI VDGRVPHAML LEILTEQAYG TMIRSH

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AAC00-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000512 Genomic DNA. Translation: ABM34680.1.
RefSeq	YP_972454.1. NC_008752.1.
3D structure databases
ProteinModelPortal	A1TUP2.
SMR	A1TUP2. Positions 13-295.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TUP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4669186.
GenomeReviews	Gene locus Aave_4139 in contig CP000512_GR.
KEGG	aav:Aave_4139.
NMPDR	fig|397945.5.peg.3544.
PATRIC	20683473. VBIAciCit38535_4201.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	A1TUP2.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	AAVE397945:AAVE_4139-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ACIAC

Accession

Primary (citable) accession number: A1TUP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program