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A1TT41 (NTPA_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:Aave_3578
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
PRO_1000068405

Regions

Region7 – 126Substrate binding By similarity
Region68 – 692Substrate binding By similarity

Sites

Metal binding391Magnesium or manganese By similarity
Metal binding681Magnesium or manganese By similarity
Binding site1571Substrate By similarity
Binding site1771Substrate By similarity
Binding site1831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1TT41 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: ACDC09B2EE46FD21

FASTA19921,504
        10         20         30         40         50         60 
MKLVLASNNR GKLAELQSMF SPLGVELVRQ ADLGVGEADE PFHTFVENAL AKARFAAEHT 

        70         80         90        100        110        120 
GLPALADDAG LCVDAFGGQP GVQTAYYATR FGYEKGDANN VRALLEQMRG VASRRAAMVS 

       130        140        150        160        170        180 
TLVAVRSPDD PEPLIAVGRV VGEIATEPRG DGGFGFDPVM FIPEFGKTFA ELPVEVKNAH 

       190 
SHRGRSAQQM LALMRERWF 

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References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000512 Genomic DNA. Translation: ABM34129.1.
RefSeqYP_971903.1. NC_008752.1.

3D structure databases

ProteinModelPortalA1TT41.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397945.Aave_3578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM34129; ABM34129; Aave_3578.
GeneID4668547.
KEGGaav:Aave_3578.
PATRIC20682321. VBIAciCit38535_3631.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
OMACEGLWHG.
OrthoDBEOG6CZQQP.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycACIT397945:GI5W-3619-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_ACIAC
AccessionPrimary (citable) accession number: A1TT41
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families