Reviewed, UniProtKB/Swiss-Prot A1TT41 (NTPA_ACIAC)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

Aave_3578

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000068405

Sequences

	Sequence		Length	Mass (Da)
	A1TT41-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: ACDC09B2EE46FD21	FASTA	199	21,504
	10 20 30 40 50 60 MKLVLASNNR GKLAELQSMF SPLGVELVRQ ADLGVGEADE PFHTFVENAL AKARFAAEHT 70 80 90 100 110 120 GLPALADDAG LCVDAFGGQP GVQTAYYATR FGYEKGDANN VRALLEQMRG VASRRAAMVS 130 140 150 160 170 180 TLVAVRSPDD PEPLIAVGRV VGEIATEPRG DGGFGFDPVM FIPEFGKTFA ELPVEVKNAH 190 SHRGRSAQQM LALMRERWF

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM34129.1.
RefSeq	YP_971903.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TT41.
Genome annotation databases
GeneID	4668547.
GenomeReviews	Gene locus Aave_3578 in contig CP000512_GR.
KEGG	aav:Aave_3578.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VYTADWA.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_ACIAC

Accession

Primary (citable) accession number: A1TT41

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)