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Protein

Catalase-peroxidase

Gene

katG

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei90 – 901Transition state stabilizerUniRule annotation
Active sitei94 – 941Proton acceptorUniRule annotation
Metal bindingi277 – 2771Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciACIT397945:GI5W-3169-MONOMER.

Protein family/group databases

PeroxiBasei5384. AavCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Aave_3132
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000002596 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Catalase-peroxidasePRO_0000354710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 236Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-262)UniRule annotation
Cross-linki236 ↔ 262Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-93)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1TRV8.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi397945.Aave_3132.

Structurei

3D structure databases

ProteinModelPortaliA1TRV8.
SMRiA1TRV8. Positions 18-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TRV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDATKCPF HAAAASGGII NKDWWPNQLR LDLLNQHSSK SDPLGAGFDY
60 70 80 90 100
AEEFKKLDYE GLKRDLRALM TDSQDWWPAD FGHYGPQFVR MTWHAAGTYR
110 120 130 140 150
TGDGRGGAGR GQQRFAPLNS WPDNVNIDKS RRLLWPIKQK YGQKISWADL
160 170 180 190 200
LVLTGNVALE TMGFRTFGFA GGREDTWEPD QDVYWGSEKT WLGGDARYGK
210 220 230 240 250
GTPGDGTLVA EPAMHGHEKD RVLENPLAAV QMGLIYVNPE GPEGNPDPVA
260 270 280 290 300
AAHDIRETFA RMAMNDEETV ALIAGGHTFG KTHGAGTADH VGPEPEAAGL
310 320 330 340 350
EQQGLGWASS FGSGKAGDAI TSGLEVTWTS TPAQWGNEFF ENLFKFEWEL
360 370 380 390 400
TKSPAGAHQW QAKNAPATIP DAHDPSKKRV PTMLTTDLSL RFDPAYEKIS
410 420 430 440 450
RRFLENPQAF AEAFARAWFK LTHRDMGPRA RYLGPEVPKE ELVWQDPIPA
460 470 480 490 500
VTHDLVDAAD VAALKARVLA SGLTVQELVG TAWASASTFR GSDKRGGANG
510 520 530 540 550
ARIRLAPQKD WAVNQPEQLA RVLQVLEGIQ REFNKGADGD KRISLADLIV
560 570 580 590 600
LAGAAGVEQA ARAAGVAVTV PFHPGRADAR QDQTDVESFS VLEPSADGFR
610 620 630 640 650
NYTKARYSVP AEVLLLDKAQ LLTLTAPEMT VLVGGLRAIN INVGGATHGV
660 670 680 690 700
FTATPGALTN DFFANLLDMS TEWKPAGDLF EGRDRKTGEK RWTGTRVDLV
710 720 730 740
FGSNSVLRSL AEVYASADAK EKFVRDFVAA WAKVMDLDRF DLR
Length:743
Mass (Da):81,229
Last modified:February 6, 2007 - v1
Checksum:iF39D462DCA067D92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA. Translation: ABM33696.1.
RefSeqiWP_011796206.1. NC_008752.1.

Genome annotation databases

EnsemblBacteriaiABM33696; ABM33696; Aave_3132.
KEGGiaav:Aave_3132.
PATRICi20681431. VBIAciCit38535_3189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA. Translation: ABM33696.1.
RefSeqiWP_011796206.1. NC_008752.1.

3D structure databases

ProteinModelPortaliA1TRV8.
SMRiA1TRV8. Positions 18-742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi397945.Aave_3132.

Protein family/group databases

PeroxiBasei5384. AavCP01.

Proteomic databases

PRIDEiA1TRV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM33696; ABM33696; Aave_3132.
KEGGiaav:Aave_3132.
PATRICi20681431. VBIAciCit38535_3189.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciACIT397945:GI5W-3169-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ACIAC
AccessioniPrimary (citable) accession number: A1TRV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.