Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1TRL2

- TRMB_ACIAC

UniProt

A1TRL2 - TRMB_ACIAC

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation
    Binding sitei106 – 1061S-adenosyl-L-methionineUniRule annotation
    Binding sitei133 – 1331S-adenosyl-L-methionineUniRule annotation
    Active sitei156 – 1561By similarity
    Binding sitei156 – 1561S-adenosyl-L-methionineUniRule annotation
    Binding sitei160 – 1601SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciACIT397945:GI5W-3069-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Aave_3033
    OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
    Taxonomic identifieri397945 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
    ProteomesiUP000002596: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249tRNA (guanine-N(7)-)-methyltransferasePRO_0000288112Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi397945.Aave_3033.

    Structurei

    3D structure databases

    ProteinModelPortaliA1TRL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni162 – 1676Interaction with RNAUniRule annotation
    Regioni227 – 2304Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1TRL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSIPADTGH TPSRAPAGNG SPPADVAFPK AIKSYVRRAG RTTTGQAKAL    50
    ETFGSQFVLD YTPGPLDAQA AFGRAAPLIL EIGFGMGEAT AHIAGVRPQD 100
    DFLCCEVHEP GVGALLKRIG ERGLTNIRIL QHDAVEVIDH MLPEGSLDGV 150
    HIFFPDPWHK KRHNKRRLVQ PPLVAKLARR LKPGGYLHCA TDWQPYAEQM 200
    LEVLSAEPLL ANSADGYAPQ PDYRPLTKFE NRGLRLGHGV WDILFRRVA 249
    Length:249
    Mass (Da):27,270
    Last modified:February 6, 2007 - v1
    Checksum:i3DC2A3556C6F50A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000512 Genomic DNA. Translation: ABM33600.1.
    RefSeqiYP_971374.1. NC_008752.1.

    Genome annotation databases

    EnsemblBacteriaiABM33600; ABM33600; Aave_3033.
    GeneIDi4666851.
    KEGGiaav:Aave_3033.
    PATRICi20681221. VBIAciCit38535_3086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000512 Genomic DNA. Translation: ABM33600.1 .
    RefSeqi YP_971374.1. NC_008752.1.

    3D structure databases

    ProteinModelPortali A1TRL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 397945.Aave_3033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM33600 ; ABM33600 ; Aave_3033 .
    GeneIDi 4666851.
    KEGGi aav:Aave_3033.
    PATRICi 20681221. VBIAciCit38535_3086.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci ACIT397945:GI5W-3069-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AAC00-1.

    Entry informationi

    Entry nameiTRMB_ACIAC
    AccessioniPrimary (citable) accession number: A1TRL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3