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A1TRH9 (A1TRH9_ACIAC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Aave_3000
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP] EMBL ABM33567.1
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323

Ontologies

Keywords
   Biological processHeme biosynthesis HAMAP MF_00323
Porphyrin biosynthesis HAMAP MF_00323
   Cellular componentCytoplasm HAMAP MF_00323
   LigandIron HAMAP MF_00323
Metal-binding HAMAP MF_00323
   Molecular functionLyase HAMAP MF_00323 EMBL ABM33567.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2101Iron By similarity HAMAP MF_00323
Metal binding2911Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A1TRH9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 09F0E32631F425B0

FASTA35438,833
        10         20         30         40         50         60 
MNASAADRSP TAPMPRTAVL LCNLGTPDAP TAPALRRYLA QFLSDPRIVE IPRAAWLPIL 

        70         80         90        100        110        120 
HGIILRIRPA KSAAKYASIW MPEGSPLAVW TERQATLLRG WLGEAGLRVQ VRHAMRYGQP 

       130        140        150        160        170        180 
SIAGQLKALQ AEGVDRVLVL PLYPQYSGTT TASVSDDVCA YALRTRRLPE LRFVNSYHDH 

       190        200        210        220        230        240 
PAYIDALARS VRAHWQREGG PAEQLVMSFH GIPERAVRLG DPYQQECLAT AALLAQALGL 

       250        260        270        280        290        300 
AADRYRVTFQ SRFGKAKWLE PYTEPTLIEM ARGGTRSVDV MCPGFTSDCL ETLEEINQEA 

       310        320        330        340        350 
REAFLHAGGK EFRYIPCLNA DNAWITALSR IAQEHLSGWD TGAPGGAAAP GLAR

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References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000512 Genomic DNA. Translation: ABM33567.1.
RefSeqYP_971341.1. NC_008752.1.

3D structure databases

ProteinModelPortalA1TRH9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TRH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4667325.
GenomeReviewsGene locus Aave_3000 in contig CP000512_GR.
KEGGaav:Aave_3000.
NMPDRfig|397945.5.peg.2554.
PATRIC20681149. VBIAciCit38535_3050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBA1TRH9.
ProtClustDBCLSK732540.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1TRH9_ACIAC
AccessionPrimary (citable) accession number: A1TRH9
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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