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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

Aave_2587

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (Aave_2587)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciACIT397945:G1G7T-2639-MONOMER
UniPathwayiUPA00564; UER00628

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:Aave_2587
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000002596 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000453951 – 303Probable 5-dehydro-4-deoxyglucarate dehydrataseAdd BLAST303

Proteomic databases

PRIDEiA1TQC1

Interactioni

Protein-protein interaction databases

STRINGi397945.Aave_2587

Structurei

3D structure databases

ProteinModelPortaliA1TQC1
SMRiA1TQC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ Bacteria
COG0329 LUCA
HOGENOMiHOG000173605
KOiK01707
OMAiRNRKKGY
OrthoDBiPOG091H00C1

Family and domain databases

CDDicd00951 KDGDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00694 KDGDH, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002220 DapA-like
IPR017655 Dehydro-deoxyglucarate_dehyd
PANTHERiPTHR12128 PTHR12128, 1 hit
PfamiView protein in Pfam
PF00701 DHDPS, 1 hit
PIRSFiPIRSF001365 DHDPS, 1 hit
SMARTiView protein in SMART
SM01130 DHDPS, 1 hit
TIGRFAMsiTIGR03249 KdgD, 1 hit

Sequencei

Sequence statusi: Complete.

A1TQC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPQELKTIM GSGLLSFPLT DFDSEGHFNA RGYAERLEWL APYGASALFA
60 70 80 90 100
AGGTGEFFSL TADEYPAIIE TAVQTCRGKV PIIAGAGGPT RFAIQCAQAA
110 120 130 140 150
EKAGAHGILL LPHYLTEAGQ EGLAAHVEAV CKSVKFGVIV YNRGQSRFTP
160 170 180 190 200
ETLARLAERN ANLVGFKDGV GDIELMNSIY MKMGDRFAYL GGLPTAEVYA
210 220 230 240 250
AAYKALGTPV YSSAVFNFIP KTAMDFYHAV ANDDQATQHR LLRSFFMPYL
260 270 280 290 300
ALRNRMPGYA VSIVKAGAKI VGHDAGPVRA PLTDLKADEM AALKALIDQL

GPQ
Length:303
Mass (Da):32,515
Last modified:February 6, 2007 - v1
Checksum:i3713975919DD2ABE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA Translation: ABM33159.1
RefSeqiWP_011795684.1, NC_008752.1

Genome annotation databases

EnsemblBacteriaiABM33159; ABM33159; Aave_2587
KEGGiaav:Aave_2587

Similar proteinsi

Entry informationi

Entry nameiKDGD_ACIAC
AccessioniPrimary (citable) accession number: A1TQC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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