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A1TQA6

- A1TQA6_ACIAC

UniProt

A1TQA6 - A1TQA6_ACIAC

Protein

Isocitrate dehydrogenase [NADP]

Gene

Aave_2572

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciACIT397945:GI5W-2604-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Aave_2572Imported
    OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)Imported
    Taxonomic identifieri397945 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
    ProteomesiUP000002596: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi397945.Aave_2572.

    Structurei

    3D structure databases

    ProteinModelPortaliA1TQA6.
    SMRiA1TQA6. Positions 7-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1TQA6-1 [UniParc]FASTAAdd to Basket

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    MTSYQHIKVP AEGQKITVNA DMSLNVPDQP IIPYIEGDGT GFDITPVMLK    50
    VVDAAVAKAY GGKRKIHWME VFAGEKSTKV YGPDVWLPEE TLHAVRDYVV 100
    SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPIQYFKGV PSPVKEPEKT 150
    NMVIFRENSE DIYAGIEFEA ESDKAKKLIK ILQEEFGVKK IRFPETSGIG 200
    VKPVSKEGTQ RLVRKAIQYA IDNDKPSVTI VHKGNIMKFT EGGFRDWAYD 250
    LAAREFGAEL IDGGPWMKFK NPRTGKEITV KDSIADAFLQ QILLRPAEYS 300
    VIATLNLNGD YVSDALAAQV GGIGIAPGAN LSDSVAMFEA THGTAPKYAG 350
    KDYVNPGSEI LSAEMMLRHM GWTEAADIII SSMEKSILSK KVTYDFARLM 400
    EGATQVSCSG FGQVMIDNM 419
    Length:419
    Mass (Da):46,009
    Last modified:February 6, 2007 - v1
    Checksum:i427022FD0E488769
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000512 Genomic DNA. Translation: ABM33144.1.
    RefSeqiWP_011795669.1. NC_008752.1.
    YP_970918.1. NC_008752.1.

    Genome annotation databases

    EnsemblBacteriaiABM33144; ABM33144; Aave_2572.
    GeneIDi4668111.
    KEGGiaav:Aave_2572.
    PATRICi20680295. VBIAciCit38535_2627.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000512 Genomic DNA. Translation: ABM33144.1 .
    RefSeqi WP_011795669.1. NC_008752.1.
    YP_970918.1. NC_008752.1.

    3D structure databases

    ProteinModelPortali A1TQA6.
    SMRi A1TQA6. Positions 7-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 397945.Aave_2572.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM33144 ; ABM33144 ; Aave_2572 .
    GeneIDi 4668111.
    KEGGi aav:Aave_2572.
    PATRICi 20680295. VBIAciCit38535_2627.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci ACIT397945:GI5W-2604-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AAC00-1Imported.

    Entry informationi

    Entry nameiA1TQA6_ACIAC
    AccessioniPrimary (citable) accession number: A1TQA6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3