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A1TQA6 (A1TQA6_ACIAC) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Aave_2572 EMBL ABM33144.1
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP] EMBL ABM33144.1
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
A1TQA6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 427022FD0E488769

FASTA41946,009
        10         20         30         40         50         60 
MTSYQHIKVP AEGQKITVNA DMSLNVPDQP IIPYIEGDGT GFDITPVMLK VVDAAVAKAY 

        70         80         90        100        110        120 
GGKRKIHWME VFAGEKSTKV YGPDVWLPEE TLHAVRDYVV SIKGPLTTPV GGGIRSLNVA 

       130        140        150        160        170        180 
LRQELDLYVC LRPIQYFKGV PSPVKEPEKT NMVIFRENSE DIYAGIEFEA ESDKAKKLIK 

       190        200        210        220        230        240 
ILQEEFGVKK IRFPETSGIG VKPVSKEGTQ RLVRKAIQYA IDNDKPSVTI VHKGNIMKFT 

       250        260        270        280        290        300 
EGGFRDWAYD LAAREFGAEL IDGGPWMKFK NPRTGKEITV KDSIADAFLQ QILLRPAEYS 

       310        320        330        340        350        360 
VIATLNLNGD YVSDALAAQV GGIGIAPGAN LSDSVAMFEA THGTAPKYAG KDYVNPGSEI 

       370        380        390        400        410 
LSAEMMLRHM GWTEAADIII SSMEKSILSK KVTYDFARLM EGATQVSCSG FGQVMIDNM 

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References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000512 Genomic DNA. Translation: ABM33144.1.
RefSeqYP_970918.1. NC_008752.1.

3D structure databases

ProteinModelPortalA1TQA6.
SMRA1TQA6. Positions 7-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397945.Aave_2572.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM33144; ABM33144; Aave_2572.
GeneID4668111.
KEGGaav:Aave_2572.
PATRIC20680295. VBIAciCit38535_2627.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000021113.
KOK00031.
OMAFRDWGYE.
OrthoDBEOG6SNDTP.
ProtClustDBPRK07006.

Enzyme and pathway databases

BioCycACIT397945:GI5W-2604-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1TQA6_ACIAC
AccessionPrimary (citable) accession number: A1TQA6
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 13, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)