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A1TQA6

- A1TQA6_ACIAC

UniProt

A1TQA6 - A1TQA6_ACIAC

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Aave_2572

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciACIT397945:GI5W-2604-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Aave_2572Imported
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)Imported
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000002596: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi397945.Aave_2572.

Structurei

3D structure databases

ProteinModelPortaliA1TQA6.
SMRiA1TQA6. Positions 7-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TQA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSYQHIKVP AEGQKITVNA DMSLNVPDQP IIPYIEGDGT GFDITPVMLK
60 70 80 90 100
VVDAAVAKAY GGKRKIHWME VFAGEKSTKV YGPDVWLPEE TLHAVRDYVV
110 120 130 140 150
SIKGPLTTPV GGGIRSLNVA LRQELDLYVC LRPIQYFKGV PSPVKEPEKT
160 170 180 190 200
NMVIFRENSE DIYAGIEFEA ESDKAKKLIK ILQEEFGVKK IRFPETSGIG
210 220 230 240 250
VKPVSKEGTQ RLVRKAIQYA IDNDKPSVTI VHKGNIMKFT EGGFRDWAYD
260 270 280 290 300
LAAREFGAEL IDGGPWMKFK NPRTGKEITV KDSIADAFLQ QILLRPAEYS
310 320 330 340 350
VIATLNLNGD YVSDALAAQV GGIGIAPGAN LSDSVAMFEA THGTAPKYAG
360 370 380 390 400
KDYVNPGSEI LSAEMMLRHM GWTEAADIII SSMEKSILSK KVTYDFARLM
410
EGATQVSCSG FGQVMIDNM
Length:419
Mass (Da):46,009
Last modified:February 6, 2007 - v1
Checksum:i427022FD0E488769
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000512 Genomic DNA. Translation: ABM33144.1.
RefSeqiYP_970918.1. NC_008752.1.

Genome annotation databases

EnsemblBacteriaiABM33144; ABM33144; Aave_2572.
GeneIDi4668111.
KEGGiaav:Aave_2572.
PATRICi20680295. VBIAciCit38535_2627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000512 Genomic DNA. Translation: ABM33144.1 .
RefSeqi YP_970918.1. NC_008752.1.

3D structure databases

ProteinModelPortali A1TQA6.
SMRi A1TQA6. Positions 7-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 397945.Aave_2572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM33144 ; ABM33144 ; Aave_2572 .
GeneIDi 4668111.
KEGGi aav:Aave_2572.
PATRICi 20680295. VBIAciCit38535_2627.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci ACIT397945:GI5W-2604-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AAC00-1Imported.

Entry informationi

Entry nameiA1TQA6_ACIAC
AccessioniPrimary (citable) accession number: A1TQA6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3