Reviewed, UniProtKB/Swiss-Prot A1TP41 (GCP_ACIAC)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Aave_2151

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303243
Sites
	Metal binding	120	1	Zinc Potential
	Metal binding	124	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A1TP41-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 780E5B978386E3DC	FASTA	348	36,320
	10 20 30 40 50 60 MVKSQLILGI ESSCDETGVA LVRAPADGSV PTLLAHALHS QIDMHQAYGG VVPELASRDH 70 80 90 100 110 120 IRRVLPLTGT VLAEADCRLA EVDVVAYTRG PGLAGALLVG AGVACALGAS LDRPVLGVHH 130 140 150 160 170 180 LEGHLLSPFL SADPPEFPFV ALLVSGGHTQ LMRVDGVGRY ELLGETIDDA AGEAFDKSAK 190 200 210 220 230 240 LLGLGYPGGP ALSRLAEQGD AAAFKLPRPL LHSGNLDFSF AGLKTAVLTQ AKKLGDELPA 250 260 270 280 290 300 RKADLAASTQ AAIVDVLVKK TLAALQASGL RRVVVAGGVG ANRLLRAQLD AACARMGVRV 310 320 330 340 HYPELHLCTD NGAMIAMAAA MRLQAGREAP NREYAFDVKP RWPLDALA

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM32729.1.
RefSeq	YP_970503.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TP41.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4668989.
GenomeReviews	Gene locus Aave_2151 in contig CP000512_GR.
KEGG	aav:Aave_2151.
NMPDR	fig|397945.5.peg.1857.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CKRALKQ.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ACIAC

Accession

Primary (citable) accession number: A1TP41

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)