Reviewed, UniProtKB/Swiss-Prot A1TNR1 (DXS_ACIAC)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	Aave_2015

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 622	622	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000018998

Sequences

	Sequence		Length	Mass (Da)
	A1TNR1-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: FDE57595A0FCB55E	FASTA	622	66,254
	10 20 30 40 50 60 MSTNSFPLLQ TVNDPADLRR MSRAQLKELA AELRAFVLDS VSKTGGHLSS NLGTVELTVA 70 80 90 100 110 120 LHTVFDTPRD RLVWDVGHQT YPHKILTGRR DRMPTLRQLG GLSGFPQRTE SEYDTFGTAH 130 140 150 160 170 180 SSTSISAALG MAMAARQRGE DRRAVAIIGD GAMTAGMAFE ALNNAGVADA NLLVILNDND 190 200 210 220 230 240 MSISPPVGAL NRYLAQLMSG QFYAAAKNVG KTVLGPVPPL LELAKRFEQQ AKGMVLPATL 250 260 270 280 290 300 FEKFGFNYIG PIDGHDLDSL IPTLENIKGL KGPQFLHVVT KKGQGYKLAE ADPVAYHGPG 310 320 330 340 350 360 KFDPSVGLTK PATPPKQTFT QVFGQWLCDM AAQDDRLVGI TPAMREGSGM VEFEKRFPGR 370 380 390 400 410 420 YYDVGIAEQH AVTFAAGMAC EGVKPVVAIY STFLQRAYDQ LIHDVALQNL PVVFALDRAG 430 440 450 460 470 480 LVGADGATHA GAYDIPFVRC IPNMSIACPA DERECRQLLS TAYAQDHPVA VRYPRGSGAG 490 500 510 520 530 540 VAPLPGLEGL PFGKGEVRRT GQRIAILAFG TLLYPALQAG ETLDATVANM RWAKPLDTAL 550 560 570 580 590 600 LLEIAAGHDA LVTVEEGAVL GGAGSAVCEA LNAAGIQKPV LQLGLPDVFI EHGDPARLLA 610 620 LQGLDAEGLV RSITARFGPA AG

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM32599.1.
RefSeq	YP_970373.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TNR1.
Genome annotation databases
GeneID	4668773.
GenomeReviews	Gene locus Aave_2015 in contig CP000512_GR.
KEGG	aav:Aave_2015.
NMPDR	fig|397945.5.peg.1740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRFPDRY.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ACIAC

Accession

Primary (citable) accession number: A1TNR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)