Reviewed, UniProtKB/Swiss-Prot A1TNJ5 (ARLY_ACIAC)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Aave_1949

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321424

Sequences

	Sequence		Length	Mass (Da)
	A1TNJ5-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 78BD1CD17331A381	FASTA	485	53,203
	10 20 30 40 50 60 MSSSPTAQPS QDQLATKAQA WSALFSEPMS DLVKRYTSSV FFDKRLWQAD IAGSLAHADM 70 80 90 100 110 120 LAAQGIISAD DHAAIRRGMA TITQEIESGA FEWKLDLEDV HLNIEARLTQ LVGDAGKRLH 130 140 150 160 170 180 TGRSRNDQVA TDVRLWLRGE IDMIADLLKE LQRSLVDVAE QNVEVILPGF THLQVAQPVS 190 200 210 220 230 240 FAHHMLAYVE MFARDAERMQ DVRRRTNVLP LGSAALAGTT YPLDRERVAR TLGMEGVCQN 250 260 270 280 290 300 SLDAVSDRDF AIEFTAAASL CMVHVSRLSE ELIIWMSQNF GFIRIADRFT TGSSIMPQKK 310 320 330 340 350 360 NPDVPELARG KTGRVVGHLM GLITLMKGQP LAYNKDNQED KEPLFDTVDT LKDTLRIFAE 370 380 390 400 410 420 MVGGQRDPAT GRKEGGITVN PQAMEQAAQK GYATATDLAD YLVKKGLPFR DAHETVAHAV 430 440 450 460 470 480 KAATSHGVDL SELPLTVLQG FHPAIGKDVF DALSLRGSLN ARNTLGGTAP AQVRTQLARH RARLG

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM32533.1.
RefSeq	YP_970307.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TNJ5.
Genome annotation databases
GeneID	4667345.
GenomeReviews	Gene locus Aave_1949 in contig CP000512_GR.
KEGG	aav:Aave_1949.
NMPDR	fig|397945.5.peg.1684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACIAC

Accession

Primary (citable) accession number: A1TNJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)