A1TNF7 (GUAC_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GMP reductase
EC=1.7.1.7

Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase

Gene names

Name:	guaC
Ordered Locus Names:	Aave_1911

Organism

Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	GMP reductase HAMAP MF_01511		PRO_0000294269
Regions
	Nucleotide binding	202 – 225	24	NADP Potential
Sites
	Active site	173	1	Thioimidate intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TNF7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 87BEE0C1DC2B1FE4	FASTA	325	35,753
	10 20 30 40 50 60 MEIFDYDNVL LLPRKCRVES RSECDASVTL GQRSFRLPVV PANMKTVVDE KICRWLASNG 70 80 90 100 110 120 YFYVMHRFDL DNVQFVRDMH AAGCFASISL GVKQPDYDTV DRLVAEGLCP EYITIDIAHG 130 140 150 160 170 180 HADTVKAMIA YLKQHLPQAF VIAGNVATPE AIIDLENWGA DATKVGVGPG KVCITKLKTG 190 200 210 220 230 240 FGTGGWQLSA LKWCARVATK PIIADGGIRS HGDIAKSIRF GATMVMIGSL FAGHEESPGK 250 260 270 280 290 300 TVEVDGEQFK EYYGSASDFN KGEYKHVEGK RILEPIKGRL ADTLVEMEQD VQSSISYSGG 310 320 RRLMDIRKVN YVILGGDNAG EHLLM

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AAC00-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000512 Genomic DNA. Translation: ABM32495.1.
RefSeq	YP_970269.1. NC_008752.1.
3D structure databases
ProteinModelPortal	A1TNF7.
SMR	A1TNF7. Positions 3-314.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TNF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4668745.
GenomeReviews	Gene locus Aave_1911 in contig CP000512_GR.
KEGG	aav:Aave_1911.
NMPDR	fig|397945.5.peg.1653.
PATRIC	20678944. VBIAciCit38535_1957.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0516.
HOGENOM	HBG298985.
OMA	PDYITID.
PhylomeDB	A1TNF7.
ProtClustDB	PRK05458.
Enzyme and pathway databases
BioCyc	AAVE397945:AAVE_1911-MONOMER.
Family and domain databases
HAMAP	MF_01511. GMP_reduct_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00364.
PANTHER	PTHR11911:SF30. PTHR11911:SF30. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMs	TIGR01306. GMP_reduct_2. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GUAC_ACIAC

Accession

Primary (citable) accession number: A1TNF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program