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Reviewed, UniProtKB/Swiss-Prot A1TND2 (TRMD_ACIAC)

Last modified November 3, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    tRNA (guanine-N(1)-)-methyltransferase
    EC=2.1.1.31
Alternative name(s):
    M1G-methyltransferase
    tRNA [GM37] methyltransferase
Gene names
Name: trmD
Ordered Locus Names: Aave_1886
OrganismAcidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity.

Catalytic activity

S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine. HAMAP MF_00605

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the RNA methyltransferase trmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtRNA modification

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
PRO_1000006441

Regions

Region137 – 1426S-adenosyl-L-methionine binding By similarity

Sites

Binding site1171S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A1TND2-1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 380C7654396BDAFF

FASTA25527,889
        10         20         30         40         50         60 
MRFDVITLFP ELFTPFLASG VTRRAYATGL VDVRFWNPRD YAEGNYRRVD DRPFGGGPGM 

        70         80         90        100        110        120 
VMMAEPLERC LRAIRADRGE APEAVAPLVM FSPIGRRLDH DGVAGWAAGN GAVLLCGRYE 

       130        140        150        160        170        180 
GVDQRFVDAH VDVQLSLGDF VLSGGEIPAM ALLDAVARLQ PGVLNDAGSH QEDSFNAALD 

       190        200        210        220        230        240 
GLLDCPHYTR PESWQGQAVP AALLSGHHAQ IERWRRDQRL AVTARHRPDL VEAARVAGRL 

       250 
DRADEAVLAK LNGLL 

« Hide

References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000512 Genomic DNA. Translation: ABM32470.1.
RefSeqYP_970244.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1TND2.

Genome annotation databases

GeneID4669343.
GenomeReviewsGene locus Aave_1886 in contig CP000512_GR.
KEGGaav:Aave_1886.
NMPDRfig|397945.5.peg.1634.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAHRSVDDT.

Family and domain databases

HAMAPMF_00605.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
[Graphical view]
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFPIRSF000386. tRNA_mtase. 1 hit.
ProDomPD004978. tRNA_m1G_mtfrase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00088. trmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_ACIAC
AccessionPrimary (citable) accession number: A1TND2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents