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Reviewed, UniProtKB/Swiss-Prot A1TNA2 (ASSY_ACIAC)

Last modified November 3, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Argininosuccinate synthase
    EC=6.3.4.5
Alternative name(s):
    Citrulline--aspartate ligase
Gene names
Name: argG
Ordered Locus Names: Aave_1856
OrganismAcidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

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Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP MF_00581

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP MF_00581

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 2 subfamily.

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Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Argininosuccinate synthase HAMAP MF_00581
PRO_1000129732

Regions

Nucleotide binding17 – 259ATP By similarity

Sites

Binding site431ATP By similarity
Binding site991Citrulline By similarity
Binding site1291ATP; via amide nitrogen By similarity
Binding site1311Aspartate By similarity
Binding site1311ATP By similarity
Binding site1351Aspartate By similarity
Binding site1351Citrulline By similarity
Binding site1361Aspartate By similarity
Binding site1361ATP By similarity
Binding site1391Citrulline By similarity
Binding site1921Citrulline By similarity
Binding site1941ATP By similarity
Binding site2011Citrulline By similarity
Binding site2031Citrulline By similarity
Binding site2801Citrulline By similarity

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Sequences

Sequence LengthMass (Da)Tools
A1TNA2-1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 587CA0231FABA622

FASTA44749,375
        10         20         30         40         50         60 
MATILQNLPA GQKVGIAFSG GLDTSAALRW MKNKGALPYA YTANLGQPDE PDYDAIPRKA 

        70         80         90        100        110        120 
MEYGAEKARL IDCRTQLAHE GIAALQAGAF HVRTAGATYF NTTPLGRAVT GTMLVAAMKE 

       130        140        150        160        170        180 
DDVHIWGDGS TFKGNDIERF YRYGLLTNPS LKIYKPWLDQ LFIDELGGRA EMSAFMTKEG 

       190        200        210        220        230        240 
FGYKMSAEKA YSTDSNMLGA THEAKDLEFL NSGMRIVNPI MGVAFWKDDV VVKAEEVSVR 

       250        260        270        280        290        300 
FEEGQPVALN GVEFNDPVEL FLEANRIGGR HGLGMCDQIE NRIIEAKSRG IYEAPGLALL 

       310        320        330        340        350        360 
HIAYERLVSG IHNEDTIEQY RMNGLKLGRL LYQGRWFDPQ AIMLRETAQR WVARAVTGTV 

       370        380        390        400        410        420 
TLELRRGNDY SILNTESPNL TYAPERLSME KVEDAPFSPA DRIGQLTMRN LDIVDTRDKL 

       430        440 
GVYAQAGLLS LGGNAALAQL GDDSSRK

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References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000512 Genomic DNA. Translation: ABM32440.1.
RefSeqYP_970214.1.

3D structure databases

SMRA1TNA2. Positions 3-440.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TNA2.

Genome annotation databases

GeneID4666594.
GenomeReviewsGene locus Aave_1856 in contig CP000512_GR.
KEGGaav:Aave_1856.
NMPDRfig|397945.5.peg.1606.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAGGRKEMS.

Family and domain databases

HAMAPMF_00581.
[Tree]
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
[Graphical view]
PANTHERPTHR11587. Arginosuc_synth. 1 hit.
PfamPF00764. Arginosuc_synth. 2 hits.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameASSY_ACIAC
AccessionPrimary (citable) accession number: A1TNA2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents