Reviewed, UniProtKB/Swiss-Prot A1TN89 (F16PA_ACIAC)

Names and origin

Protein names

Recommended name:
    Fructose-1,6-bisphosphatase class 1
      Short name=FBPase class 1
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	Aave_1843

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364445
Regions
	Region	117 – 120	4	Substrate binding By similarity
Sites
	Metal binding	92	1	Magnesium 1 By similarity
	Metal binding	114	1	Magnesium 1 By similarity
	Metal binding	114	1	Magnesium 2 By similarity
	Metal binding	116	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	117	1	Magnesium 2 By similarity
	Metal binding	281	1	Magnesium 2 By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	275	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TN89-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 73A2638802E86336	FASTA	335	37,144
	10 20 30 40 50 60 MAQRISLTRY LVEQQRVDGL IPSQLRLLLE VVARACKHIS HAVNKGALGG VLGSASSENV 70 80 90 100 110 120 QGEIQKKLDI IANEVLIEAN EWGGHLAAMA SEEMDSIYVV PNRYPQGEYL LLFDPLDGSS 130 140 150 160 170 180 NIDVNVSIGT IFSVLKKPEG HPGVTTEDFL QAGSSQVAAG YCIYGPQTTL VLTVGDGVAM 190 200 210 220 230 240 FTLDREQGSF VLVEENVKIP ADTREFAINM SNMRHWDAPV KRYIDECLAG TEGPREKDFN 250 260 270 280 290 300 MRWIASMVAD VHRILTRGGI FLYPWDKREP NKPGKLRLMY EANPMSWLIE QAGGAATNGK 310 320 330 ERILDIQPKQ LHERVSVILG SKNEVERVTR YHSGI

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM32427.1.
RefSeq	YP_970201.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TN89.
Genome annotation databases
GeneID	4668743.
GenomeReviews	Gene locus Aave_1843 in contig CP000512_GR.
KEGG	aav:Aave_1843.
NMPDR	fig|397945.5.peg.1595.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRHWEAP.
Family and domain databases
HAMAP	MF_01855. [Tree]
InterPro	IPR000146. Fructose_bisphosphatase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PRINTS	PR00115. F16BPHPHTASE.
ProDom	PD001491. In_FB_phphtase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_ACIAC

Accession

Primary (citable) accession number: A1TN89

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)