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A1TMI2 (A1TMI2_ACIAC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108
Gene names
Name:ispD HAMAP MF_00108
Ordered Locus Names:Aave_1581
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP] EMBL ABM32170.1
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site321Transition state stabilizer By similarity HAMAP MF_00108
Site441Transition state stabilizer By similarity HAMAP MF_00108
Site1791Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2321Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A1TMI2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 96D7479F1A1F3A92

FASTA27428,351
        10         20         30         40         50         60 
MSDLLPPRPT LPPPATPGRF WALLPCAGTG ARAVAPGAAA GVPKQYQAVA GLPLVLHTLA 

        70         80         90        100        110        120 
AFAGVRRLLG TLVAVAPGDA FFDAHPSELH FAVACGGATR ADTVLGGLRA LRERGAGEGD 

       130        140        150        160        170        180 
WVLVHDAARC LVTTAQIDAL IDACEHDSVG GLLAHKLADT LKTASEGPGG VRVASTVDRS 

       190        200        210        220        230        240 
DKWLAQTPQM FRLGTLESAL VRYGAQATDE ASAMEAMGLH PRLVPGGAQN FKVTYPDDFA 

       250        260        270 
LAEAVLAQRL LPATLERFGG PLAQGAPLPG KTFF

« Hide

References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000512 Genomic DNA. Translation: ABM32170.1.
RefSeqYP_969944.1. NC_008752.1.

3D structure databases

ProteinModelPortalA1TMI2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TMI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4667710.
GenomeReviewsGene locus Aave_1581 in contig CP000512_GR.
KEGGaav:Aave_1581.
NMPDRfig|397945.5.peg.1391.
PATRIC20678262. VBIAciCit38535_1629.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1211.
HOGENOMHBG672839.
OMAFPQGAIL.
PhylomeDBA1TMI2.
ProtClustDBCLSK963069.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1TMI2_ACIAC
AccessionPrimary (citable) accession number: A1TMI2
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info