A1TLB7 (OTC_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	Aave_1163

Organism

Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065069
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	263 – 266	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TLB7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: D47C3F3AC8B7DDDD	FASTA	309	34,599
	10 20 30 40 50 60 MKAPSDMKHY LQFKDFSAQE YAYLFERAAV IKGKFKRYEK HHPLTDRTLA MIFEKASTRT 70 80 90 100 110 120 RVSFEAGMYQ LGGSVVHLTT GDSQLGRAEP IEDSAKVISR MVDLVMIRTY EQTKIERFAA 130 140 150 160 170 180 HSRVPVINGL TNEFHPCQIL ADIFTFIEHR GSIQGRTVAW VGDGNNMANT WLQAAELLGF 190 200 210 220 230 240 TVHVSTPSGY EVDSRVAGVA AGSHYKVFSD PLEACRGADL ITTDVWTSMG YEAENEARKK 250 260 270 280 290 300 AFADWCVDAE MMAAARPEAL FMHCLPAHRG EEVEADVIDG PQSVVWDEAE NRMHVQKALM EYLLLGQVA

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AAC00-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000512 Genomic DNA. Translation: ABM31755.1.
RefSeq	YP_969529.1. NC_008752.1.
3D structure databases
ProteinModelPortal	A1TLB7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TLB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4669557.
GenomeReviews	Gene locus Aave_1163 in contig CP000512_GR.
KEGG	aav:Aave_1163.
NMPDR	fig|397945.5.peg.1014.
PATRIC	20677364. VBIAciCit38535_1186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	GVDCVVT.
PhylomeDB	A1TLB7.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	AAVE397945:AAVE_1163-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ACIAC

Accession

Primary (citable) accession number: A1TLB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program