Reviewed, UniProtKB/Swiss-Prot A1TKZ0 (HIS8_ACIAC)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	Aave_1031

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000063454
Amino acid modifications
	Modified residue	231	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TKZ0-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B45E5F857B5A84DA	FASTA	370	39,825
	10 20 30 40 50 60 MTDTLAAALG RIRPDVRAMH AYAVQPATGV LKMDAMENPF PLPPELQEAL GRRLGALALN 70 80 90 100 110 120 RYPGARLTDL KSALAAHIGM PEGFSMVLGN GSDEIITLLA LACARPGTGE RAAMLAPMPG 130 140 150 160 170 180 FVMYPMSAQL QGLDFVAVPL TADFELDEPA MLAAIAQHRP AITYLAYPNN PTATLWDEGA 190 200 210 220 230 240 VQRVIDAAGA QGGIVVMDEA YQPFASRTWL DRMRAEPVRN AHVLLMRTLS KFGLAGVRLG 250 260 270 280 290 300 YLAGPAALVD EIEKVRPPYN VSVLNCEAAL FALEHARVFA AQAAELRAVR TRLVAALRAM 310 320 330 340 350 360 PGIERVWDSE ANMVLVRVPD AARAFEGMKA RKVLVKNVST MHPLLARCLR LTVGSEADNA 370 QMLDALQASL

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM31628.1.
RefSeq	YP_969402.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TKZ0.
Genome annotation databases
GeneID	4669638.
GenomeReviews	Gene locus Aave_1031 in contig CP000512_GR.
KEGG	aav:Aave_1031.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PAWINEL.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_ACIAC

Accession

Primary (citable) accession number: A1TKZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)