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A1TKW2 (AROK_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate kinase
Short name=SK
EC=2.7.1.71
Gene names
Name:aroK
Ordered Locus Names:Aave_1002
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109

Catalytic activity

ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109

Subunit structure

Monomer By similarity. HAMAP MF_00109

Subcellular location

Cytoplasm Probable HAMAP MF_00109.

Sequence similarities

Belongs to the shikimate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

shikimate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Shikimate kinase HAMAP MF_00109
PRO_1000022960

Regions

Nucleotide binding15 – 206ATP By similarity

Sites

Metal binding191Magnesium By similarity
Binding site371Substrate By similarity
Binding site611Substrate By similarity
Binding site851Substrate; via amide nitrogen By similarity
Binding site1231ATP By similarity
Binding site1421Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1TKW2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 25708EA14B27C233

FASTA18320,417
        10         20         30         40         50         60 
MRGPQLSIHL IGLPGSGKST VGRHLARRLG LPFIDSDHVI EQRIGGSIRG FFDREGEAAF 

        70         80         90        100        110        120 
RDLEEEVILE LTEANVPPQV LATGGGVVIR PGNRTRLRER GTVVYLNASP EEIFRHIRHD 

       130        140        150        160        170        180 
QTRPLLQVGS PLDRLRELQR ERDPLYREAA HFVISPERGK NVAALVQHIA MQLELAGIRP 


PSP

« Hide

References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000512 Genomic DNA. Translation: ABM31600.1.
RefSeqYP_969374.1. NC_008752.1.

3D structure databases

ProteinModelPortalA1TKW2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TKW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4666908.
GenomeReviewsGene locus Aave_1002 in contig CP000512_GR.
KEGGaav:Aave_1002.
PATRIC20677027. VBIAciCit38535_1018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0703.
HOGENOMHBG335815.
OMAVIYLRAN.
PhylomeDBA1TKW2.

Enzyme and pathway databases

BioCycAAVE397945:AAVE_1002-MONOMER.

Family and domain databases

HAMAPMF_00109. Shikimate_kinase.
[Tree]
InterProIPR000623. Shikimate_kinase.
IPR023000. Shikimate_kinase_CS.
[Graphical view]
KOK00891.
PfamPF01202. SKI. 1 hit.
[Graphical view]
PRINTSPR01100. SHIKIMTKNASE.
PROSITEPS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROK_ACIAC
AccessionPrimary (citable) accession number: A1TKW2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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