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A1TKC8 (MRAY_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Aave_0818
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002926

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane314 – 33421Helical; Potential
Transmembrane369 – 38921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1TKC8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 80A150114097D972

FASTA39243,149
        10         20         30         40         50         60 
MLLMLSQWLQ GLSPEFGFFR VFQYLTFRAV MAAMTALLIG LLAGPKVIRM LTALKIGQPI 

        70         80         90        100        110        120 
RGYAMESHLS KSGTPTMGGV LILGAIAIST LLWFDLSNRF VWVVLAVTLG FGAIGWVDDW 

       130        140        150        160        170        180 
RKVVRKDPEG MRSREKYFWQ SVIGIVAALY LVFCISENSN ARVFELFVTW IQSGFSMDLP 

       190        200        210        220        230        240 
PQAGLLVPFF KEVSYPLGVL GFVILTYLVI VGSSNAVNLT DGLDGLAIMP VVMVGASLGV 

       250        260        270        280        290        300 
FAYVTGSAVY SKYLLFPYIA GAGELLIFCS AMAGAGLAFL WFNTHPAQVF MGDVGALALG 

       310        320        330        340        350        360 
GALGTIAIIV RQEIVLAIMG GIFVVEALSV MLQVTWFKYT KRRYGEGRRL LKMAPLHHHF 

       370        380        390 
EKSGWKETQV VVRFWIITML LCLIGLTTLK LR

« Hide

References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000512 Genomic DNA. Translation: ABM31416.1.
RefSeqYP_969190.1. NC_008752.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1TKC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4668576.
GenomeReviewsGene locus Aave_0818 in contig CP000512_GR.
KEGGaav:Aave_0818.
NMPDRfig|397945.5.peg.709.
PATRIC20676663. VBIAciCit38535_0837.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMAQVGYFKW.
PhylomeDBA1TKC8.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycAAVE397945:AAVE_0818-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACIAC
AccessionPrimary (citable) accession number: A1TKC8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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