Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1TI06

- SYL_MYCVP

UniProt

A1TI06 - SYL_MYCVP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei744 – 7441ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-6112-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mvan_6054
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 968968Leucine--tRNA ligasePRO_0000334779Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350058.Mvan_6054.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi75 – 8612"HIGH" regionAdd
    BLAST
    Motifi741 – 7455"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1TI06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTETPTGTQS SRETAADDTP RHRYTAGLAG EIERAWQQRW TQDGTFDVAN    50
    PVGSLAPADG SAVPADKMFV QDMFPYPSGE GLHVGHPLGY IATDVYARYY 100
    RMTGRNVLHA LGFDAFGLPA EQYAIQTGTH PRTRTEANIV NFRRQLGRLG 150
    LGHDSRRSFS TTDVDFYKWT QWIFLQIYNA WFDTAQNKAR PVAELIAEFE 200
    AGTREVGDGR RWADLDAGER ADVVDSRRLV YLADSVVNWC PGLGTVLANE 250
    EVTSDGRSER GNFPVFRKRL RQWMMRITAY SDRLLEDLDV LDWPDKVKTM 300
    QRNWIGRSTG ASVEFGTDAG DIEVFTTRPD TLFGATYMVL APEHDLVDRL 350
    VADQWPADVD ARWTFGAATP REAVAAYRAS IAAKSDLERQ ENKAKTGVFI 400
    GAYATNPANA KQVPVFIADY VLAGYGTGAI MAVPGGDQRD WDFATEFGLP 450
    IIEVVRPVAD RPGEDTGAGG DVSQAAYTGD GVMVNSGFLD GMDVSAAKEA 500
    MTERLSADGR GRERVEYKLR DWLFARQRYW GEPFPIVYDA DDRAHGLPEE 550
    LLPVELPDVP DYSPVLFDPD DADSEPSPPL AKATEWVNVE LDLGDGRKRY 600
    TRDTNVMPQW AGSSWYELRY ADPHNTEALC AKENEAYWMG PRPAEHGPDD 650
    PGGVDLYVGG VEHAVLHLLY SRFWHKVLYD LGHVSSREPY RRLVNQGYIQ 700
    AFAYTDARGS YVPAAEVVER DGKFFWPGPD GEIEVNQEFG KIGKSLKNSV 750
    SPDEICDDYG ADTLRVYEMS MGPLEASRPW ATKDVVGAHR FLQRVWRLVV 800
    SEETGETVVT DDALDEDTLR LLHRTIAGTA DDYAALRNNT AAAKLIEYTN 850
    HLTKQSVTAR AALEPLVLMV APLAPHLAEE LWRRLGHDAS LAHGPFPVAD 900
    ERYLVEDTVE YPVQVNGKVR GRVTVAADAP ADAVEAAALA DDKVVAFLDG 950
    KTPKKVIVVA GRLVNVVL 968
    Length:968
    Mass (Da):107,296
    Last modified:February 6, 2007 - v1
    Checksum:i332228120EF1A332
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM16806.1.
    RefSeqiYP_956812.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM16806; ABM16806; Mvan_6054.
    GeneIDi4644030.
    KEGGimva:Mvan_6054.
    PATRICi18190584. VBIMycVan31953_6178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM16806.1 .
    RefSeqi YP_956812.1. NC_008726.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_6054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM16806 ; ABM16806 ; Mvan_6054 .
    GeneIDi 4644030.
    KEGGi mva:Mvan_6054.
    PATRICi 18190584. VBIMycVan31953_6178.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MVAN350058:GIWR-6112-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiSYL_MYCVP
    AccessioniPrimary (citable) accession number: A1TI06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3