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A1TI06

- SYL_MYCVP

UniProt

A1TI06 - SYL_MYCVP

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Protein

Leucine--tRNA ligase

Gene
leuS, Mvan_6054
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei744 – 7441ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-6112-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mvan_6054
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Leucine--tRNA ligaseUniRule annotationPRO_0000334779Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_6054.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi75 – 8612"HIGH" regionUniRule annotationAdd
BLAST
Motifi741 – 7455"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TI06-1 [UniParc]FASTAAdd to Basket

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MTETPTGTQS SRETAADDTP RHRYTAGLAG EIERAWQQRW TQDGTFDVAN    50
PVGSLAPADG SAVPADKMFV QDMFPYPSGE GLHVGHPLGY IATDVYARYY 100
RMTGRNVLHA LGFDAFGLPA EQYAIQTGTH PRTRTEANIV NFRRQLGRLG 150
LGHDSRRSFS TTDVDFYKWT QWIFLQIYNA WFDTAQNKAR PVAELIAEFE 200
AGTREVGDGR RWADLDAGER ADVVDSRRLV YLADSVVNWC PGLGTVLANE 250
EVTSDGRSER GNFPVFRKRL RQWMMRITAY SDRLLEDLDV LDWPDKVKTM 300
QRNWIGRSTG ASVEFGTDAG DIEVFTTRPD TLFGATYMVL APEHDLVDRL 350
VADQWPADVD ARWTFGAATP REAVAAYRAS IAAKSDLERQ ENKAKTGVFI 400
GAYATNPANA KQVPVFIADY VLAGYGTGAI MAVPGGDQRD WDFATEFGLP 450
IIEVVRPVAD RPGEDTGAGG DVSQAAYTGD GVMVNSGFLD GMDVSAAKEA 500
MTERLSADGR GRERVEYKLR DWLFARQRYW GEPFPIVYDA DDRAHGLPEE 550
LLPVELPDVP DYSPVLFDPD DADSEPSPPL AKATEWVNVE LDLGDGRKRY 600
TRDTNVMPQW AGSSWYELRY ADPHNTEALC AKENEAYWMG PRPAEHGPDD 650
PGGVDLYVGG VEHAVLHLLY SRFWHKVLYD LGHVSSREPY RRLVNQGYIQ 700
AFAYTDARGS YVPAAEVVER DGKFFWPGPD GEIEVNQEFG KIGKSLKNSV 750
SPDEICDDYG ADTLRVYEMS MGPLEASRPW ATKDVVGAHR FLQRVWRLVV 800
SEETGETVVT DDALDEDTLR LLHRTIAGTA DDYAALRNNT AAAKLIEYTN 850
HLTKQSVTAR AALEPLVLMV APLAPHLAEE LWRRLGHDAS LAHGPFPVAD 900
ERYLVEDTVE YPVQVNGKVR GRVTVAADAP ADAVEAAALA DDKVVAFLDG 950
KTPKKVIVVA GRLVNVVL 968
Length:968
Mass (Da):107,296
Last modified:February 6, 2007 - v1
Checksum:i332228120EF1A332
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM16806.1.
RefSeqiYP_956812.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM16806; ABM16806; Mvan_6054.
GeneIDi4644030.
KEGGimva:Mvan_6054.
PATRICi18190584. VBIMycVan31953_6178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM16806.1 .
RefSeqi YP_956812.1. NC_008726.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_6054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM16806 ; ABM16806 ; Mvan_6054 .
GeneIDi 4644030.
KEGGi mva:Mvan_6054.
PATRICi 18190584. VBIMycVan31953_6178.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-6112-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiSYL_MYCVP
AccessioniPrimary (citable) accession number: A1TI06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi