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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei744ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-6155-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mvan_6054
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347791 – 968Leucine--tRNA ligaseAdd BLAST968

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_6054

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi75 – 86"HIGH" regionAdd BLAST12
Motifi741 – 745"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1TI06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETPTGTQS SRETAADDTP RHRYTAGLAG EIERAWQQRW TQDGTFDVAN
60 70 80 90 100
PVGSLAPADG SAVPADKMFV QDMFPYPSGE GLHVGHPLGY IATDVYARYY
110 120 130 140 150
RMTGRNVLHA LGFDAFGLPA EQYAIQTGTH PRTRTEANIV NFRRQLGRLG
160 170 180 190 200
LGHDSRRSFS TTDVDFYKWT QWIFLQIYNA WFDTAQNKAR PVAELIAEFE
210 220 230 240 250
AGTREVGDGR RWADLDAGER ADVVDSRRLV YLADSVVNWC PGLGTVLANE
260 270 280 290 300
EVTSDGRSER GNFPVFRKRL RQWMMRITAY SDRLLEDLDV LDWPDKVKTM
310 320 330 340 350
QRNWIGRSTG ASVEFGTDAG DIEVFTTRPD TLFGATYMVL APEHDLVDRL
360 370 380 390 400
VADQWPADVD ARWTFGAATP REAVAAYRAS IAAKSDLERQ ENKAKTGVFI
410 420 430 440 450
GAYATNPANA KQVPVFIADY VLAGYGTGAI MAVPGGDQRD WDFATEFGLP
460 470 480 490 500
IIEVVRPVAD RPGEDTGAGG DVSQAAYTGD GVMVNSGFLD GMDVSAAKEA
510 520 530 540 550
MTERLSADGR GRERVEYKLR DWLFARQRYW GEPFPIVYDA DDRAHGLPEE
560 570 580 590 600
LLPVELPDVP DYSPVLFDPD DADSEPSPPL AKATEWVNVE LDLGDGRKRY
610 620 630 640 650
TRDTNVMPQW AGSSWYELRY ADPHNTEALC AKENEAYWMG PRPAEHGPDD
660 670 680 690 700
PGGVDLYVGG VEHAVLHLLY SRFWHKVLYD LGHVSSREPY RRLVNQGYIQ
710 720 730 740 750
AFAYTDARGS YVPAAEVVER DGKFFWPGPD GEIEVNQEFG KIGKSLKNSV
760 770 780 790 800
SPDEICDDYG ADTLRVYEMS MGPLEASRPW ATKDVVGAHR FLQRVWRLVV
810 820 830 840 850
SEETGETVVT DDALDEDTLR LLHRTIAGTA DDYAALRNNT AAAKLIEYTN
860 870 880 890 900
HLTKQSVTAR AALEPLVLMV APLAPHLAEE LWRRLGHDAS LAHGPFPVAD
910 920 930 940 950
ERYLVEDTVE YPVQVNGKVR GRVTVAADAP ADAVEAAALA DDKVVAFLDG
960
KTPKKVIVVA GRLVNVVL
Length:968
Mass (Da):107,296
Last modified:February 6, 2007 - v1
Checksum:i332228120EF1A332
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM16806.1
RefSeqiWP_011783150.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM16806; ABM16806; Mvan_6054
KEGGimva:Mvan_6054

Similar proteinsi

Entry informationi

Entry nameiSYL_MYCVP
AccessioniPrimary (citable) accession number: A1TI06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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