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A1TI06

- SYL_MYCVP

UniProt

A1TI06 - SYL_MYCVP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei744 – 7441ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-6112-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mvan_6054
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Leucine--tRNA ligasePRO_0000334779Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_6054.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi75 – 8612"HIGH" regionAdd
BLAST
Motifi741 – 7455"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TI06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTETPTGTQS SRETAADDTP RHRYTAGLAG EIERAWQQRW TQDGTFDVAN
60 70 80 90 100
PVGSLAPADG SAVPADKMFV QDMFPYPSGE GLHVGHPLGY IATDVYARYY
110 120 130 140 150
RMTGRNVLHA LGFDAFGLPA EQYAIQTGTH PRTRTEANIV NFRRQLGRLG
160 170 180 190 200
LGHDSRRSFS TTDVDFYKWT QWIFLQIYNA WFDTAQNKAR PVAELIAEFE
210 220 230 240 250
AGTREVGDGR RWADLDAGER ADVVDSRRLV YLADSVVNWC PGLGTVLANE
260 270 280 290 300
EVTSDGRSER GNFPVFRKRL RQWMMRITAY SDRLLEDLDV LDWPDKVKTM
310 320 330 340 350
QRNWIGRSTG ASVEFGTDAG DIEVFTTRPD TLFGATYMVL APEHDLVDRL
360 370 380 390 400
VADQWPADVD ARWTFGAATP REAVAAYRAS IAAKSDLERQ ENKAKTGVFI
410 420 430 440 450
GAYATNPANA KQVPVFIADY VLAGYGTGAI MAVPGGDQRD WDFATEFGLP
460 470 480 490 500
IIEVVRPVAD RPGEDTGAGG DVSQAAYTGD GVMVNSGFLD GMDVSAAKEA
510 520 530 540 550
MTERLSADGR GRERVEYKLR DWLFARQRYW GEPFPIVYDA DDRAHGLPEE
560 570 580 590 600
LLPVELPDVP DYSPVLFDPD DADSEPSPPL AKATEWVNVE LDLGDGRKRY
610 620 630 640 650
TRDTNVMPQW AGSSWYELRY ADPHNTEALC AKENEAYWMG PRPAEHGPDD
660 670 680 690 700
PGGVDLYVGG VEHAVLHLLY SRFWHKVLYD LGHVSSREPY RRLVNQGYIQ
710 720 730 740 750
AFAYTDARGS YVPAAEVVER DGKFFWPGPD GEIEVNQEFG KIGKSLKNSV
760 770 780 790 800
SPDEICDDYG ADTLRVYEMS MGPLEASRPW ATKDVVGAHR FLQRVWRLVV
810 820 830 840 850
SEETGETVVT DDALDEDTLR LLHRTIAGTA DDYAALRNNT AAAKLIEYTN
860 870 880 890 900
HLTKQSVTAR AALEPLVLMV APLAPHLAEE LWRRLGHDAS LAHGPFPVAD
910 920 930 940 950
ERYLVEDTVE YPVQVNGKVR GRVTVAADAP ADAVEAAALA DDKVVAFLDG
960
KTPKKVIVVA GRLVNVVL
Length:968
Mass (Da):107,296
Last modified:February 6, 2007 - v1
Checksum:i332228120EF1A332
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM16806.1.
RefSeqiYP_956812.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM16806; ABM16806; Mvan_6054.
GeneIDi4644030.
KEGGimva:Mvan_6054.
PATRICi18190584. VBIMycVan31953_6178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM16806.1 .
RefSeqi YP_956812.1. NC_008726.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_6054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM16806 ; ABM16806 ; Mvan_6054 .
GeneIDi 4644030.
KEGGi mva:Mvan_6054.
PATRICi 18190584. VBIMycVan31953_6178.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-6112-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiSYL_MYCVP
AccessioniPrimary (citable) accession number: A1TI06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3