A1TG95 (A1TG95_MYCVP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	Mvan_5425

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	663 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABM16195.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	536	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	629	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A1TG95 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E5700E2D8AAAEF75	FASTA	663	72,891
	10 20 30 40 50 60 MQRLVTTLTT MTETQLDAIA SYPPPPEFTE SANATAELYD EAEADRLAFW AKQANRLSWQ 70 80 90 100 110 120 TPFTEVLDWS DAPFAKWFVG GKLNVAYNCV DRHVEAGNGD RVAIHWEGEP VGDARDITYA 130 140 150 160 170 180 QLKDEVCQAA NAFAELGLKA GDRVAIYMPM VPEAIIAMLA CARLGAMHSV VFAGFSASAL 190 200 210 220 230 240 KARIEDAQTK LVVTTDGQYR RGSAVALKTA VDEAIESLGD DNPVEHVVVV RRTGIDIAWT 250 260 270 280 290 300 QGRDVLWEEV VPKASTEHTP EAFDSEHPLF LLYTSGTTGK PKGIMHTSGG YLTQASYTHY 310 320 330 340 350 360 NVFDIKPETD VYWCTADIGW VTGHTYIVYG PLSNGATQVV YEGTPASPDE HRHFQVIEKY 370 380 390 400 410 420 GVTIYYTAPT LVRTFMKWGR QLPAEHDLSS LRLLGSVGEP INPEAWRWYR LAFGGDNTPV 430 440 450 460 470 480 VDTWWQTETG GIMISPLPGV THCKPGSAMR ALPGISAKIV DDDGNELEPS PDYGEHVTGY 490 500 510 520 530 540 LVLDKPWPAM LRGIWGDEER FRETYWSRFA EKGWYFAGDG ARYGTDGEIW VLGRIDDVMN 550 560 570 580 590 600 ISGHRISTAE VESALVGHSG VAEAAVVGAS DEHTGQAICA FVILKSSAHG GEANMVDELR 610 620 630 640 650 660 AEVAREISPI AKPREIHVVP ELPKTRSGKI MRRLLRDVAE GRELGDTSTL LDPSVFEAIR ASK

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM16195.1.
RefSeq	YP_956201.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1TG95.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TG95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000079492; EBMYCP00000077445; EBMYCG00000079487.
GeneID	4646618.
GenomeReviews	Gene locus Mvan_5425 in contig CP000511_GR.
KEGG	mva:Mvan_5425.
PATRIC	18189265. VBIMycVan31953_5526.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
GeneTree	EBGT00050000015141.
HOGENOM	HBG547964.
OMA	RARINSM.
PhylomeDB	A1TG95.
ProtClustDB	PRK00174.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1TG95_MYCVP

Accession

Primary (citable) accession number: A1TG95

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)