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A1TG35

- PANC_MYCVP

UniProt

A1TG35 - PANC_MYCVP

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Protein
Pantothenate synthetase
Gene
panC, Mvan_5364
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton donor By similarity
Binding sitei75 – 751Beta-alanine By similarity
Binding sitei75 – 751Pantoate By similarity
Binding sitei167 – 1671Pantoate By similarity
Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATP By similarity
Nucleotide bindingi161 – 1644ATP By similarity
Nucleotide bindingi198 – 2014ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-5413-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Mvan_5364
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Pantothenate synthetaseUniRule annotation
PRO_0000305493Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_5364.

Structurei

3D structure databases

ProteinModelPortaliA1TG35.
SMRiA1TG35. Positions 7-291.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1TG35-1 [UniParc]FASTAAdd to Basket

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MTRRDTPKFT AGQLNVYTRP GDVAAVTRAL RATGRRIVLV PTMGALHEGH    50
LTLIRAAKRV TGAVVVVSIF VNPLQFAANE DLGAYPRTLD ADLDALRAEG 100
VDIAFTPTAD DMYPNGMRTT VHPGPLGAEL EGALRPTHFA GVLTVVLKLF 150
NTVRPDRAYF GEKDFQQLAL IRQMVTDLDL EVEIQGVPIV REPDGLAMSS 200
RNRYLDAVQR EQAGALSAAL LAGMYAAGEG TAAAVDAARA VLDEVPAIEV 250
DYLEVRDAML GPAPEVGMGR MLVAGRLGAT RLLDNIAIDI GVPSGPGRQA 300
EFDEHELPWR N 311
Length:311
Mass (Da):33,414
Last modified:February 6, 2007 - v1
Checksum:i160FE4B04E03F504
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM16135.1.
RefSeqiYP_956141.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM16135; ABM16135; Mvan_5364.
GeneIDi4647080.
KEGGimva:Mvan_5364.
PATRICi18189143. VBIMycVan31953_5466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM16135.1 .
RefSeqi YP_956141.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1TG35.
SMRi A1TG35. Positions 7-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_5364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM16135 ; ABM16135 ; Mvan_5364 .
GeneIDi 4647080.
KEGGi mva:Mvan_5364.
PATRICi 18189143. VBIMycVan31953_5466.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci MVAN350058:GIWR-5413-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiPANC_MYCVP
AccessioniPrimary (citable) accession number: A1TG35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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