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A1TG35

- PANC_MYCVP

UniProt

A1TG35 - PANC_MYCVP

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Protein

Pantothenate synthetase

Gene

panC

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton donorUniRule annotation
Binding sitei75 – 751Beta-alanineUniRule annotation
Binding sitei75 – 751PantoateUniRule annotation
Binding sitei167 – 1671PantoateUniRule annotation
Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATPUniRule annotation
Nucleotide bindingi161 – 1644ATPUniRule annotation
Nucleotide bindingi198 – 2014ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-5413-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Mvan_5364
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Pantothenate synthetasePRO_0000305493Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_5364.

Structurei

3D structure databases

ProteinModelPortaliA1TG35.
SMRiA1TG35. Positions 7-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1TG35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRRDTPKFT AGQLNVYTRP GDVAAVTRAL RATGRRIVLV PTMGALHEGH
60 70 80 90 100
LTLIRAAKRV TGAVVVVSIF VNPLQFAANE DLGAYPRTLD ADLDALRAEG
110 120 130 140 150
VDIAFTPTAD DMYPNGMRTT VHPGPLGAEL EGALRPTHFA GVLTVVLKLF
160 170 180 190 200
NTVRPDRAYF GEKDFQQLAL IRQMVTDLDL EVEIQGVPIV REPDGLAMSS
210 220 230 240 250
RNRYLDAVQR EQAGALSAAL LAGMYAAGEG TAAAVDAARA VLDEVPAIEV
260 270 280 290 300
DYLEVRDAML GPAPEVGMGR MLVAGRLGAT RLLDNIAIDI GVPSGPGRQA
310
EFDEHELPWR N
Length:311
Mass (Da):33,414
Last modified:February 6, 2007 - v1
Checksum:i160FE4B04E03F504
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM16135.1.
RefSeqiYP_956141.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM16135; ABM16135; Mvan_5364.
GeneIDi4647080.
KEGGimva:Mvan_5364.
PATRICi18189143. VBIMycVan31953_5466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM16135.1 .
RefSeqi YP_956141.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1TG35.
SMRi A1TG35. Positions 7-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_5364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM16135 ; ABM16135 ; Mvan_5364 .
GeneIDi 4647080.
KEGGi mva:Mvan_5364.
PATRICi 18189143. VBIMycVan31953_5466.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci MVAN350058:GIWR-5413-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiPANC_MYCVP
AccessioniPrimary (citable) accession number: A1TG35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3