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Protein

Xylose isomerase

Gene

xylA

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651UniRule annotation
Active sitei68 – 681UniRule annotation
Metal bindingi192 – 1921Magnesium 1UniRule annotation
Metal bindingi228 – 2281Magnesium 1UniRule annotation
Metal bindingi228 – 2281Magnesium 2UniRule annotation
Metal bindingi231 – 2311Magnesium 2UniRule annotation
Metal bindingi256 – 2561Magnesium 1UniRule annotation
Metal bindingi266 – 2661Magnesium 2UniRule annotation
Metal bindingi268 – 2681Magnesium 2UniRule annotation
Metal bindingi304 – 3041Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-5343-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Mvan_5294Imported
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)Imported
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_5294.

Structurei

3D structure databases

ProteinModelPortaliA1TFW5.
SMRiA1TFW5. Positions 18-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000022596.
KOiK01805.
OMAiPADKFSF.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TFW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLESSRPV PDALSPRRED KFSFGLWTVG WPGVDPFGVA TRPALDAIEA
60 70 80 90 100
VDRLAALGAY GLTFHDDDLF AFGSSDGERR RAIDRLTSAL SANGLVVPMV
110 120 130 140 150
TTNLFTQPVF KDGGFTSNDR AVRRFALRKV LRNLDLAAEL GAQTFVMWGG
160 170 180 190 200
REGGEYDSAK DVQAALERYR EALDVLCQYV IDQGSGIRFA IEPKPNEPRG
210 220 230 240 250
DILLPTVGHA LAFIETLAHP EMVGVNPETG HEQMSGLNFT HGIAQALYSG
260 270 280 290 300
KLFHIDLNGQ RGIKFDQDLV FGHGDLVNAF SLVDLLEHGG PDGGPAYDGP
310 320 330 340 350
RHFDYKPSRT EDAEGVWASA AANMRMYLLL RQRAAAFRAD PDVREAMVAA
360 370 380 390 400
KVAELRKPTL AAGETYADLL NDRSAYEEFD TGAYFGGKGC GFVALHQLAV

EHLMGAR
Length:407
Mass (Da):44,346
Last modified:February 5, 2007 - v1
Checksum:iC0E2CD3933F951C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM16065.1.
RefSeqiWP_011782435.1. NC_008726.1.
YP_956071.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM16065; ABM16065; Mvan_5294.
KEGGimva:Mvan_5294.
PATRICi18189001. VBIMycVan31953_5395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM16065.1.
RefSeqiWP_011782435.1. NC_008726.1.
YP_956071.1. NC_008726.1.

3D structure databases

ProteinModelPortaliA1TFW5.
SMRiA1TFW5. Positions 18-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_5294.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM16065; ABM16065; Mvan_5294.
KEGGimva:Mvan_5294.
PATRICi18189001. VBIMycVan31953_5395.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000022596.
KOiK01805.
OMAiPADKFSF.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-5343-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1Imported.

Entry informationi

Entry nameiA1TFW5_MYCVP
AccessioniPrimary (citable) accession number: A1TFW5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2007
Last sequence update: February 5, 2007
Last modified: March 31, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.