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Protein

L-ectoine synthase

Gene

ectC

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.UniRule annotation

Catalytic activityi

N4-acetyl-L-2,4-diaminobutanoate = L-ectoine + H2O.UniRule annotation

Pathwayi: ectoine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. L-ectoine synthase (ectC)
This subpathway is part of the pathway ectoine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde, the pathway ectoine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-5356-MONOMER
UniPathwayiUPA00067; UER00123

Names & Taxonomyi

Protein namesi
Recommended name:
L-ectoine synthaseUniRule annotation (EC:4.2.1.108UniRule annotation)
Alternative name(s):
N-acetyldiaminobutyrate dehydrataseUniRule annotation
Gene namesi
Name:ectCUniRule annotation
Ordered Locus Names:Mvan_5272
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000672341 – 130L-ectoine synthaseAdd BLAST130

Proteomic databases

PRIDEiA1TFU3

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_5272

Structurei

3D structure databases

ProteinModelPortaliA1TFU3
SMRiA1TFU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ectoine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z6K Bacteria
ENOG4111NEJ LUCA
HOGENOMiHOG000078059
KOiK06720
OMAiDNMGFSF
OrthoDBiPOG091H05Q0

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_01255 Ectoine_synth, 1 hit
InterProiView protein in InterPro
IPR010462 Ectoine_synth
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR39289 PTHR39289, 1 hit
PfamiView protein in Pfam
PF06339 Ectoine_synth, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD080544 Ectoine_synth, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

A1TFU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVRTTDEIT GTNRDVAAEH WRSKRIILAD DGVGFSFHET TIDANSVSEF
60 70 80 90 100
HYQHHVEAVW VVEGTGTLTN HETGEVHPLR PGTMYLLNGH ERHRVTCDTT
110 120 130
MRMLCVFNPP VTGREIHDEN GAYPAAVQAS
Length:130
Mass (Da):14,566
Last modified:February 6, 2007 - v1
Checksum:i46D58D5DE2BA68CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM16043.1
RefSeqiWP_011782413.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM16043; ABM16043; Mvan_5272
KEGGimva:Mvan_5272

Similar proteinsi

Entry informationi

Entry nameiECTC_MYCVP
AccessioniPrimary (citable) accession number: A1TFU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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