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Protein

L-ectoine synthase

Gene

ectC

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.UniRule annotation

Catalytic activityi

N(4)-acetyl-L-2,4-diaminobutanoate = L-ectoine + H2O.UniRule annotation

Pathwayi: ectoine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. L-ectoine synthase (ectC)
This subpathway is part of the pathway ectoine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ectoine from L-aspartate 4-semialdehyde, the pathway ectoine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-5321-MONOMER.
UniPathwayiUPA00067; UER00123.

Names & Taxonomyi

Protein namesi
Recommended name:
L-ectoine synthaseUniRule annotation (EC:4.2.1.108UniRule annotation)
Alternative name(s):
N-acetyldiaminobutyrate dehydrataseUniRule annotation
Gene namesi
Name:ectCUniRule annotation
Ordered Locus Names:Mvan_5272
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130L-ectoine synthasePRO_1000067234Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_5272.

Structurei

3D structure databases

ProteinModelPortaliA1TFU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ectoine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z6K. Bacteria.
ENOG4111NEJ. LUCA.
HOGENOMiHOG000078059.
KOiK06720.
OMAiCVFNPPI.
OrthoDBiPOG091H05Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01255. Ectoine_synth. 1 hit.
InterProiIPR010462. Ectoine_synth.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06339. Ectoine_synth. 1 hit.
[Graphical view]
ProDomiPD080544. Ectoine_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

A1TFU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVRTTDEIT GTNRDVAAEH WRSKRIILAD DGVGFSFHET TIDANSVSEF
60 70 80 90 100
HYQHHVEAVW VVEGTGTLTN HETGEVHPLR PGTMYLLNGH ERHRVTCDTT
110 120 130
MRMLCVFNPP VTGREIHDEN GAYPAAVQAS
Length:130
Mass (Da):14,566
Last modified:February 6, 2007 - v1
Checksum:i46D58D5DE2BA68CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM16043.1.
RefSeqiWP_011782413.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM16043; ABM16043; Mvan_5272.
KEGGimva:Mvan_5272.
PATRICi18188957. VBIMycVan31953_5373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM16043.1.
RefSeqiWP_011782413.1. NC_008726.1.

3D structure databases

ProteinModelPortaliA1TFU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_5272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM16043; ABM16043; Mvan_5272.
KEGGimva:Mvan_5272.
PATRICi18188957. VBIMycVan31953_5373.

Phylogenomic databases

eggNOGiENOG4108Z6K. Bacteria.
ENOG4111NEJ. LUCA.
HOGENOMiHOG000078059.
KOiK06720.
OMAiCVFNPPI.
OrthoDBiPOG091H05Q0.

Enzyme and pathway databases

UniPathwayiUPA00067; UER00123.
BioCyciMVAN350058:GIWR-5321-MONOMER.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01255. Ectoine_synth. 1 hit.
InterProiIPR010462. Ectoine_synth.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06339. Ectoine_synth. 1 hit.
[Graphical view]
ProDomiPD080544. Ectoine_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiECTC_MYCVP
AccessioniPrimary (citable) accession number: A1TFU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.