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Protein

Acetaldehyde dehydrogenase 3

Gene

Mvan_5235

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei277NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi158 – 166NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-5319-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:Mvan_5235
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876941 – 306Acetaldehyde dehydrogenase 3Add BLAST306

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_5235

Structurei

3D structure databases

ProteinModelPortaliA1TFQ6
SMRiA1TFQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A1TFQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKKSVAIV GSGNISTDLL YKLLRSEWLE PRWMIGIDPE SEGLARARKL
60 70 80 90 100
GLETSHEGVD WLLAQSELPD MVFEATSAYV HKAAAPRYAE AGIRAIDLTP
110 120 130 140 150
AAVGPGVIPP ANLRAHLDAP NVNMVTCGGQ ATIPMVYAVS RVVEVPYAEI
160 170 180 190 200
VASVSSASAG PGTRANIDEF TKTTSAGVQN IGGAQRGKAI IILNPAEPPM
210 220 230 240 250
IMRDTIFCAI PEHADHAAIT QSIKDVVAEV QTYVPGYRLL NEPQFDEPSV
260 270 280 290 300
VNGGNHVVTV FVEVEGAGDY LPPYAGNLDI MTAAATKVGE EIAKESLAAT

AGGAQA
Length:306
Mass (Da):32,183
Last modified:February 6, 2007 - v1
Checksum:iDFAFD67A97536A35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM16006.1
RefSeqiWP_011782376.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM16006; ABM16006; Mvan_5235
KEGGimva:Mvan_5235

Similar proteinsi

Entry informationi

Entry nameiACDH3_MYCVP
AccessioniPrimary (citable) accession number: A1TFQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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