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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Mvan_5145)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-5221-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Mvan_5138
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000187411 – 301Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST301

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_5138

Structurei

3D structure databases

ProteinModelPortaliA1TFF9
SMRiA1TFF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V Bacteria
COG0152 LUCA
HOGENOMiHOG000230360
KOiK01923
OMAiEMVIRGY
OrthoDBiPOG091H01GT

Family and domain databases

HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR001636 SAICAR_synth
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A1TFF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPALTDYQH LASGKVRELY RIDGGHLLFV ATDRISAYDH ILKSEIPDKG
60 70 80 90 100
RVLTAMSVFF FDYLSRTAAV SNHLAGPPDD ERIPEEVLGR ALVVEQLEML
110 120 130 140 150
PVEAVARGYL TGSGLIDYQQ TGTVCGIALP SGLVEASRFD EPLFTPATKA
160 170 180 190 200
ELGEHDVNIS FDDVVGLIGA ERAEELRDRT LRTYSQGAAH ALTRGIIVAD
210 220 230 240 250
TKFEFGVDAR GELKLADEVF TPDSSRYWRA DDYAEGQVQN SFDKQFVRNW
260 270 280 290 300
LTGPDSGWDR HGDQPPPPLP PDIVDATRAR YIEAYERISG LRFDDWIGVS

A
Length:301
Mass (Da):33,400
Last modified:February 6, 2007 - v1
Checksum:i868010B699499CCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM15909.1
RefSeqiWP_011782279.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM15909; ABM15909; Mvan_5138
KEGGimva:Mvan_5138

Similar proteinsi

Entry informationi

Entry nameiPUR7_MYCVP
AccessioniPrimary (citable) accession number: A1TFF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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