A1TFD2 (A1TFD2_MYCVP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Ordered Locus Names:

Mvan_5111

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733 EMBL ABM15882.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1TFD2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 0563C327853B6B78	FASTA	384	40,566
	10 20 30 40 50 60 MAGSPTTCAE RTPGRIGCSR RPVALWPMSD RAEQHGISYA SAGVDIEAGD RAVELFKPLA 70 80 90 100 110 120 KKATRPEVRG GLGGFAGLFA LRGDYREPLL ASSTDGVGTK LAVAQAMDKH DTVGIDLVAM 130 140 150 160 170 180 VVDDLVVCGA EPLFLQDYIA VGRTVPERVA ELVSGIADGC VLAGCALLGG ETAEHPGLMA 190 200 210 220 230 240 PDHYDISATG IGVVEADDVL GPDRVRPGDV IIGMASTGLH SNGYSLARHV LLEIDHMNLA 250 260 270 280 290 300 GHVEEFGRTL GEELLEPTRI YAKDCLALAA ETQVRTFCHV TGGGLAGNLE RVIPHGLVAE 310 320 330 340 350 360 LDRGTWTPAP VFGMIAQRGR IERAEMEKTF NMGVGMVAIV APEDTDRALA VLTARHLNCW 370 380 TLGTIEKGGK DGPRAVLVGQ HPRF

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM15882.1.
RefSeq	YP_955888.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1TFD2.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TFD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000078191; EBMYCP00000076144; EBMYCG00000078186.
GeneID	4647548.
GenomeReviews	Gene locus Mvan_5111 in contig CP000511_GR.
KEGG	mva:Mvan_5111.
PATRIC	18188627. VBIMycVan31953_5209.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1TFD2_MYCVP

Accession

Primary (citable) accession number: A1TFD2

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)