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A1TEL7

- MPRA_MYCVP

UniProt

A1TEL7 - MPRA_MYCVP

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Protein
Response regulator MprA
Gene
mprA, Mvan_4844
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. response to stress Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-4887-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene namesi
Name:mprA
Ordered Locus Names:Mvan_4844
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Response regulator MprA
PRO_0000308430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 4814-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated and dephosphorylated by MprB By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_4844.

Structurei

3D structure databases

ProteinModelPortaliA1TEL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 118115Response regulatory
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK07669.
OMAiCKAIRSK.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TEL7-1 [UniParc]FASTAAdd to Basket

« Hide

MPVRILVVDD DRAVRESLRR SLSFNGYSVE LAQDGREALD LIASDRPDAV    50
VLDVMMPRLD GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY 100
LPKPFALEEL LARMRALLRR TTPDDGAGES AAMTFSDLSL DPVTREVTRG 150
DRPISLTRTE FSLLEMLIAN PRRVLTRSRI LEEVWGFDFP TSGNALEVYV 200
GYLRRKTEAE GEPRLIHTVR GVGYVLRETP P 231
Length:231
Mass (Da):25,767
Last modified:February 6, 2007 - v1
Checksum:iF0D8D15D137014D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM15617.1.
RefSeqiYP_955623.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM15617; ABM15617; Mvan_4844.
GeneIDi4646410.
KEGGimva:Mvan_4844.
PATRICi18188065. VBIMycVan31953_4933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM15617.1 .
RefSeqi YP_955623.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1TEL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_4844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM15617 ; ABM15617 ; Mvan_4844 .
GeneIDi 4646410.
KEGGi mva:Mvan_4844.
PATRICi 18188065. VBIMycVan31953_4933.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034815.
KOi K07669.
OMAi CKAIRSK.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-4887-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiMPRA_MYCVP
AccessioniPrimary (citable) accession number: A1TEL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi