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A1TE33 (COAA_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pantothenate kinase
EC=2.7.1.33
Alternative name(s):
Pantothenic acid kinase
Gene names
Name:coaA
Ordered Locus Names:Mvan_4658
OrganismMycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]
Taxonomic identifier350058 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215

Subcellular location

Cytoplasm Probable HAMAP MF_00215.

Sequence similarities

Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantothenate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Pantothenate kinase HAMAP MF_00215
PRO_1000043234

Regions

Nucleotide binding97 – 1048ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A1TE33 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C763ED891C1162D7

FASTA31235,461
        10         20         30         40         50         60 
MARLSEPSPY VEFDRTQWRA LRMSTPLKLT EDELVRLRGL GEKIDLLEVE EVYLPLARLI 

        70         80         90        100        110        120 
HLQVAARQAL FATTAQFLGE PQQNPDRPVP FIIGVAGSVA VGKSTTARVL QALLARWEHH 

       130        140        150        160        170        180 
PRVDLVTTDG FLYSNSELSR RNLMHRKGFP ESYDRRGLMR FVTAIKSGAD AACAPVYSHL 

       190        200        210        220        230        240 
LYDIVAGEKQ IIEHPDILIL EGLNVLQTGP ALMVSDLFDF SVYVDARIED IENWYISRFL 

       250        260        270        280        290        300 
SMRAGAFADP ASHFHHYSTL TDEQAVFAAR DIWHSINRPN LIENILPTRP RATLVLRKDS 

       310 
DHSINRLRLR KL

« Hide

References

[1]"Complete sequence of Mycobacterium vanbaalenii PYR-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000511 Genomic DNA. Translation: ABM15433.1.
RefSeqYP_955439.1. NC_008726.1.

3D structure databases

ProteinModelPortalA1TE33.
SMRA1TE33. Positions 5-312.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TE33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000080280; EBMYCP00000078233; EBMYCG00000080275.
GeneID4649222.
GenomeReviewsGene locus Mvan_4658 in contig CP000511_GR.
KEGGmva:Mvan_4658.
PATRIC18187675. VBIMycVan31953_4741.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1072.
GeneTreeEBGT00050000016369.
HOGENOMHBG732538.
OMAEVYLPLS.
PhylomeDBA1TE33.
ProtClustDBPRK05439.

Enzyme and pathway databases

BioCycMVAN350058:MVAN_4658-MONOMER.

Family and domain databases

HAMAPMF_00215. Pantothen_kinase_1.
[Tree]
InterProIPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
KOK00867.
PANTHERPTHR10285:SF7. PanK_bact. 1 hit.
PfamPF00485. PRK. 1 hit.
[Graphical view]
PIRSFPIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMsTIGR00554. PanK_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAA_MYCVP
AccessionPrimary (citable) accession number: A1TE33
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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