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A1TDB8

- ACDH2_MYCVP

UniProt

A1TDB8 - ACDH2_MYCVP

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Protein
Acetaldehyde dehydrogenase 2
Gene
Mvan_4392
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Binding sitei288 – 2881NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 124NAD By similarity
Nucleotide bindingi160 – 1689NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-4432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:Mvan_4392
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Acetaldehyde dehydrogenase 2UniRule annotation
PRO_0000387693Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_4392.

Structurei

3D structure databases

ProteinModelPortaliA1TDB8.
SMRiA1TDB8. Positions 3-310.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A1TDB8-1 [UniParc]FASTAAdd to Basket

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MRKVAIIGSG NIGTDLMIKV LRVSDLLEVA AMVGIDPDSD GLARARRLKV    50
QTTHEGVEGL LALDEFDEID IVFDATSAGA HIKNAETLRK FGKYLVDLTP 100
AAIGPFVVPA VNLTDQLNRN VDNVNMVTCG GQATIPIVAA VSQVTPVAYA 150
EIVASISSKS AGPGTRANID EFTETTAQAI ESVGGAARGK AIIILNPADP 200
PVIMRDTVLC LTGDVDQDAV RDSVSTMVEE VSRYVPGYHL KQEVQFDRVS 250
AADVRTLLPA GVGTVSTQIS VFLEVEGAAH YLPAYAGNLD IMTSAALRVG 300
EGIAERLNHA EAPRRSRA 318
Length:318
Mass (Da):33,600
Last modified:February 6, 2007 - v1
Checksum:iA6F0161BAF5FA310
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM15168.1.
RefSeqiWP_011781546.1. NC_008726.1.
YP_955174.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM15168; ABM15168; Mvan_4392.
GeneIDi4648731.
KEGGimva:Mvan_4392.
PATRICi18187123. VBIMycVan31953_4465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM15168.1 .
RefSeqi WP_011781546.1. NC_008726.1.
YP_955174.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1TDB8.
SMRi A1TDB8. Positions 3-310.
ModBasei Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_4392.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM15168 ; ABM15168 ; Mvan_4392 .
GeneIDi 4648731.
KEGGi mva:Mvan_4392.
PATRICi 18187123. VBIMycVan31953_4465.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-4432-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiACDH2_MYCVP
AccessioniPrimary (citable) accession number: A1TDB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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