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A1TDB8

- ACDH2_MYCVP

UniProt

A1TDB8 - ACDH2_MYCVP

Protein

Acetaldehyde dehydrogenase 2

Gene

Mvan_4392

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
    Binding sitei288 – 2881NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 124NADUniRule annotation
    Nucleotide bindingi160 – 1689NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-4432-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Ordered Locus Names:Mvan_4392
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Acetaldehyde dehydrogenase 2PRO_0000387693Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350058.Mvan_4392.

    Structurei

    3D structure databases

    ProteinModelPortaliA1TDB8.
    SMRiA1TDB8. Positions 3-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiFTETTAH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1TDB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKVAIIGSG NIGTDLMIKV LRVSDLLEVA AMVGIDPDSD GLARARRLKV    50
    QTTHEGVEGL LALDEFDEID IVFDATSAGA HIKNAETLRK FGKYLVDLTP 100
    AAIGPFVVPA VNLTDQLNRN VDNVNMVTCG GQATIPIVAA VSQVTPVAYA 150
    EIVASISSKS AGPGTRANID EFTETTAQAI ESVGGAARGK AIIILNPADP 200
    PVIMRDTVLC LTGDVDQDAV RDSVSTMVEE VSRYVPGYHL KQEVQFDRVS 250
    AADVRTLLPA GVGTVSTQIS VFLEVEGAAH YLPAYAGNLD IMTSAALRVG 300
    EGIAERLNHA EAPRRSRA 318
    Length:318
    Mass (Da):33,600
    Last modified:February 6, 2007 - v1
    Checksum:iA6F0161BAF5FA310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM15168.1.
    RefSeqiWP_011781546.1. NC_008726.1.
    YP_955174.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM15168; ABM15168; Mvan_4392.
    GeneIDi4648731.
    KEGGimva:Mvan_4392.
    PATRICi18187123. VBIMycVan31953_4465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM15168.1 .
    RefSeqi WP_011781546.1. NC_008726.1.
    YP_955174.1. NC_008726.1.

    3D structure databases

    ProteinModelPortali A1TDB8.
    SMRi A1TDB8. Positions 3-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_4392.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM15168 ; ABM15168 ; Mvan_4392 .
    GeneIDi 4648731.
    KEGGi mva:Mvan_4392.
    PATRICi 18187123. VBIMycVan31953_4465.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi FTETTAH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci MVAN350058:GIWR-4432-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiACDH2_MYCVP
    AccessioniPrimary (citable) accession number: A1TDB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3