A1TDB8 (ACDH2_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 2
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2

Gene names

Ordered Locus Names:

Mvan_4392

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Acetaldehyde dehydrogenase 2 HAMAP MF_01657		PRO_0000387693
Regions
	Nucleotide binding	9 – 12	4	NAD By similarity
	Nucleotide binding	160 – 168	9	NAD By similarity
Sites
	Binding site	288	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TDB8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: A6F0161BAF5FA310	FASTA	318	33,600
	10 20 30 40 50 60 MRKVAIIGSG NIGTDLMIKV LRVSDLLEVA AMVGIDPDSD GLARARRLKV QTTHEGVEGL 70 80 90 100 110 120 LALDEFDEID IVFDATSAGA HIKNAETLRK FGKYLVDLTP AAIGPFVVPA VNLTDQLNRN 130 140 150 160 170 180 VDNVNMVTCG GQATIPIVAA VSQVTPVAYA EIVASISSKS AGPGTRANID EFTETTAQAI 190 200 210 220 230 240 ESVGGAARGK AIIILNPADP PVIMRDTVLC LTGDVDQDAV RDSVSTMVEE VSRYVPGYHL 250 260 270 280 290 300 KQEVQFDRVS AADVRTLLPA GVGTVSTQIS VFLEVEGAAH YLPAYAGNLD IMTSAALRVG 310 EGIAERLNHA EAPRRSRA

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM15168.1.
RefSeq	YP_955174.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1TDB8.
SMR	A1TDB8. Positions 3-310.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TDB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000080765; EBMYCP00000078718; EBMYCG00000080760.
GeneID	4648731.
GenomeReviews	Gene locus Mvan_4392 in contig CP000511_GR.
KEGG	mva:Mvan_4392.
PATRIC	18187123. VBIMycVan31953_4465.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
GeneTree	EBGT00050000016468.
HOGENOM	HBG300125.
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_4392-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH2_MYCVP

Accession

Primary (citable) accession number: A1TDB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program