A1TC97 (IOLG2_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase 2
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase 2
Short name=MI 2-dehydrogenase 2

Gene names

Name:	iolG2
Ordered Locus Names:	Mvan_4020

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Inositol 2-dehydrogenase 2 HAMAP MF_01671		PRO_0000352578

Sequences

	Sequence		Length	Mass (Da)
	A1TC97 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8E95AFF8C535F794	FASTA	342	36,999
	10 20 30 40 50 60 MSELRVAVLG VGVMGADHVA RITSRISGAR VSVVNDYVTE KAEQIASEVD GCRAVVDPLD 70 80 90 100 110 120 AIADPEVDAV VLATPGSTHE KQLLACLDHR KPVMCEKPLT TDVFTSLEIA RREAELECPL 130 140 150 160 170 180 IQVGFMRRFD DEYMRLKALL DGGELGQPLV MHCVHRNPGV PSYFDSSLIV KDSLVHEVDV 190 200 210 220 230 240 TRYLFGEEIA SVQIVRPVSN PAAPEGVIDP QIAILRTVSG RHVDVELFVT TGVAYEVRTE 250 260 270 280 290 300 VVGERGSAMI GLDVGLIRKS APGTWGGLIA PGFRERFGRA YDTEIQRWVD AVRAGTNIDG 310 320 330 340 PTAWDGYAAA AVCAAGVESL ESGLPVPVHL AERPDRSTIR PR

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM14797.1.
RefSeq	YP_954803.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1TC97.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TC97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000080488; EBMYCP00000078441; EBMYCG00000080483.
GeneID	4647476.
GenomeReviews	Gene locus Mvan_4020 in contig CP000511_GR.
KEGG	mva:Mvan_4020.
PATRIC	18186353. VBIMycVan31953_4090.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
GeneTree	EBGT00050000017284.
HOGENOM	HBG612336.
OMA	RTEVVGE.
ProtClustDB	CLSK956652.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_4020-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG2_MYCVP

Accession

Primary (citable) accession number: A1TC97

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program