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A1TC20

- PROB_MYCVP

UniProt

A1TC20 - PROB_MYCVP

Protein

Glutamate 5-kinase

Gene

proB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171ATPUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Binding sitei144 – 1441SubstrateUniRule annotation
    Binding sitei156 – 1561Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi176 – 1772ATPUniRule annotation
    Nucleotide bindingi216 – 2227ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-3973-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:Mvan_3943
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Glutamate 5-kinasePRO_1000081079Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350058.Mvan_3943.

    Structurei

    3D structure databases

    ProteinModelPortaliA1TC20.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini278 – 35679PUAUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation
    Contains 1 PUA domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiFDAKEIP.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SMARTiSM00359. PUA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1TC20-1 [UniParc]FASTAAdd to Basket

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    MSAHRDAIRT ARSVVVKIGT TALTTPTGVF DTSRLQDLAD AIEARMKAGS    50
    DVVIVSSGAI AAGIEPLGLT KRPTDLATKQ AAASVGQVAL VNTWSSAFGR 100
    YHRTVGQVLL TAHDISMRVQ HTNAQRTLDR LRALHAVAIV NENDTVATNE 150
    IRFGDNDRLS ALVAHLVGAD ALILLSDVDG LYDSDPRKGN ARFIPEVDGP 200
    DDLEGVTAGR GSHLGTGGMV SKLSSALLAA DAGVPVLLAA ASDAAAALDG 250
    ASVGTVFAPR KERMSARRFW VRYAAEASGA LTLDDGAVKA VVRQRRSLLP 300
    AGITALSGRF YGGDVVELRN QDATMVARGV VAYDAAELAT MLGRSTSDLP 350
    AEMRRPAVHA DDLVAV 366
    Length:366
    Mass (Da):38,250
    Last modified:February 6, 2007 - v1
    Checksum:i04F22EED2918616C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM14720.1.
    RefSeqiWP_011781100.1. NC_008726.1.
    YP_954726.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM14720; ABM14720; Mvan_3943.
    GeneIDi4646234.
    KEGGimva:Mvan_3943.
    PATRICi18186195. VBIMycVan31953_4011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM14720.1 .
    RefSeqi WP_011781100.1. NC_008726.1.
    YP_954726.1. NC_008726.1.

    3D structure databases

    ProteinModelPortali A1TC20.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_3943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM14720 ; ABM14720 ; Mvan_3943 .
    GeneIDi 4646234.
    KEGGi mva:Mvan_3943.
    PATRICi 18186195. VBIMycVan31953_4011.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi FDAKEIP.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci MVAN350058:GIWR-3973-MONOMER.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SMARTi SM00359. PUA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiPROB_MYCVP
    AccessioniPrimary (citable) accession number: A1TC20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3