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A1TBI4 (A1TBI4_MYCVP) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:Mvan_3752
OrganismMycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]
Taxonomic identifier350058 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length924 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A1TBI4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 554F34643B4FC1D8

FASTA924103,074
        10         20         30         40         50         60 
MRQDLAQNSG STAEPDRVRV IREGVASYLP DIDPEETGEW LESFDDLLER SGPARARYLM 

        70         80         90        100        110        120 
LRLLERSREK RVAIPALTST DYVNTIPTEL EPWFPGDEDV ERRYRAWIRW NAAIMVHRAQ 

       130        140        150        160        170        180 
RPGVGVGGHI STYASSAALY EVGFNHFFRG KSHPGGGDQI FIQGHASPGI YARAYLEGRL 

       190        200        210        220        230        240 
SADQLDGFRQ EHSHPGGGLP SYPHPRLMPD FWEFPTVSMG LGPMNAIYQA RFNHYLHDRG 

       250        260        270        280        290        300 
IKDTSKQHVW AFLGDGEMDE PESRGLIQVA ANEALDNLTF VVNCNLQRLD GPVRGNGKII 

       310        320        330        340        350        360 
QELESFFRGA GWNVIKVVWG REWDALLHAD RDGALVNLMN TTPDGDYQTY KANDGAYVRD 

       370        380        390        400        410        420 
HFFGRDPRTK ALVENMTDRE IWNLKRGGHD YRKVYAAYHA ALEHKGQPTV ILAKTIKGYT 

       430        440        450        460        470        480 
LGKHFEGRNA THQMKKLALQ DLKDFRDAQR IPVSDEQLEA DPYLPPYYHP GPEAPEIRYM 

       490        500        510        520        530        540 
LDRRRALGGF LPERRTKSRA LTLPGRDVYK ALKKGSGKQE VATTMATVRT FKELLRDKNI 

       550        560        570        580        590        600 
GSRIVPIIPD EARTFGMDSW FPSLKIYNRN GQLYTAVDAE LMLAYKESEI GQILHEGINE 

       610        620        630        640        650        660 
AGSTASFTAV GTSYATHNEP MIPIYIFYSM FGFQRTGDGL WAAADQMARG FVLGATAGRT 

       670        680        690        700        710        720 
TLVGEGLQHA DGHSLLLAST NPAVVAYDPA FAYEIAYIIE SGLHRMYGEN PENVYFYMTI 

       730        740        750        760        770        780 
YNEPYVQPAE PDGLDVEGLL RGMYRYQAAP EKRTNAAQIL VSGVGMPSAL KAAELLAQEW 

       790        800        810        820        830        840 
DVAADVWSVT SWGELNRDGV AIEREKLRHP ELPAATPYVT KMLAEAAGPV VAVSDWMRAV 

       850        860        870        880        890        900 
PEQIRPWVPG TYITLGTDGF GFSDTRPAAR RYYNTDAESV VVAVLEGLAR DGNIDISVAV 

       910        920 
EAAKKYEIDD VMAAPEQTSD PGVA

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References

[1]"Complete sequence of Mycobacterium vanbaalenii PYR-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000511 Genomic DNA. Translation: ABM14534.1.
RefSeqYP_954540.1. NC_008726.1.

3D structure databases

ProteinModelPortalA1TBI4.
SMRA1TBI4. Positions 80-915.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TBI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000078060; EBMYCP00000076013; EBMYCG00000078055.
GeneID4646818.
GenomeReviewsGene locus Mvan_3752 in contig CP000511_GR.
KEGGmva:Mvan_3752.
PATRIC18185797. VBIMycVan31953_3813.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
GeneTreeEBGT00050000016271.
HOGENOMHBG289271.
OMAFRQEKSH.
PhylomeDBA1TBI4.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1TBI4_MYCVP
AccessionPrimary (citable) accession number: A1TBI4
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info