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A1TAA5 (ARLY_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Mvan_3307
OrganismMycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]
Taxonomic identifier350058 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_1000000512

Sequences

Sequence LengthMass (Da)Tools
A1TAA5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 1C8242D3CC399B0D

FASTA47049,957
        10         20         30         40         50         60 
MSTNEGSLWG GRFADGPADA LAALSKSTHF DWVLAPYDVV ASKAHARVLF RAGLLTEEQR 

        70         80         90        100        110        120 
DGLLAGLDSL GSDVADGSFG PLVSDEDVHG ALERGLIDRV GADLGGRLRA GRSRNDQVAT 

       130        140        150        160        170        180 
LFRLWLRDAI RRVADGVLEV VAALATQAAA HPTAIMPGKT HLQSAQPVLL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDVDRLAD FDKRAAVSPY GSGALAGSSL GLDPDAIAEE LGFAAAADNS IDATASRDFA 

       250        260        270        280        290        300 
AEAAFVFSMI GVDLSRLAED IILWSTTEFG YVTLHDAWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLAG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAMAGL VGTLRFDVDR 

       370        380        390        400        410        420 
MAELAPLGYT LATDVAEWLV RRGVPFRVAH EAAGAAVRAA EARGIGLEDL ADAELTGIHP 

       430        440        450        460        470 
QLTADVREVL TTEGSVNSRD ARGGTAPTQV ARQLSAVRDT SERFRVRLRR

« Hide

References

[1]"Complete sequence of Mycobacterium vanbaalenii PYR-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000511 Genomic DNA. Translation: ABM14105.1.
RefSeqYP_954111.1. NC_008726.1.

3D structure databases

ProteinModelPortalA1TAA5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1TAA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000081104; EBMYCP00000079057; EBMYCG00000081099.
GeneID4644890.
GenomeReviewsGene locus Mvan_3307 in contig CP000511_GR.
KEGGmva:Mvan_3307.
PATRIC18184901. VBIMycVan31953_3368.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMVAN350058:MVAN_3307-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCVP
AccessionPrimary (citable) accession number: A1TAA5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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