A1TA72 (DER_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Der

Alternative name(s):
GTP-binding protein EngA

Gene names

Name:	der
Synonyms:	engA
Ordered Locus Names:	Mvan_3274

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195
Subunit structure	Associates with the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Der subfamily. Contains 2 G (guanine nucleotide-binding) domains. Contains 1 KH-like domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Domain	Repeat
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	GTPase Der HAMAP MF_00195		PRO_1000011674
Regions
	Domain	43 – 148	106	G 1
	Domain	217 – 325	109	G 2
	Domain	379 – 462	84	KH-like
	Nucleotide binding	38 – 45	8	GTP 1 Potential
	Nucleotide binding	85 – 89	5	GTP 1 Potential
	Nucleotide binding	147 – 150	4	GTP 1 Potential
	Nucleotide binding	212 – 219	8	GTP 2 Potential
	Nucleotide binding	259 – 263	5	GTP 2 Potential
	Nucleotide binding	324 – 327	4	GTP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	A1TA72 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E3FFFE71E1610F49	FASTA	470	50,859
	10 20 30 40 50 60 MTDDGTWSDE SDWELGPDDI SDAIEEVSAP PPVVAVVGRP NVGKSTLVNR ILGRREAVVQ 70 80 90 100 110 120 DVPGVTRDRV SYDASWSGQR FMVQDTGGWE PDAKGLQQLV AEQASVAMRT ADAIIFVVDS 130 140 150 160 170 180 VVGATAADEA AAKLLQRSGK PVFLAANKVD NERGEADAAA LWSLGLGEPH PISAMHGRGV 190 200 210 220 230 240 ADLLDAVVDA LPTISEVAGA GGGGPRRVAL VGKPNVGKSS LLNRLSGDER SVVHDVAGTT 250 260 270 280 290 300 VDPVDSLIEM DGKLWRFVDT AGLRRKVGQA SGHEFYASVR THGAIDAAEV AIVLVDASQP 310 320 330 340 350 360 LTEQDQRVLS MVVEAGRALV LAFNKWDLVD EDRRYLLDRE IDLQLAQLQW APRVNISAKT 370 380 390 400 410 420 GRAVQKLVPA LETALKSWDT RVSTGRLNTF FKEIVAATPP PVRGGKQPRI LFATQATARP 430 440 450 460 470 PTFVLFTTGF LEAGYRRFLE RRLRETFGFE GSPIRINVRV REKRGPKARR

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM14072.1.
RefSeq	YP_954078.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1TA72.
ModBase	Search...
Protein-protein interaction databases
STRING	A1TA72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000079151; EBMYCP00000077104; EBMYCG00000079146.
GeneID	4644491.
GenomeReviews	Gene locus Mvan_3274 in contig CP000511_GR.
KEGG	mva:Mvan_3274.
PATRIC	18184827. VBIMycVan31953_3334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1160.
GeneTree	EBGT00050000016947.
HOGENOM	HBG592135.
OMA	LAVNKCE.
ProtClustDB	PRK03003.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_3274-MONOMER.
Family and domain databases
HAMAP	MF_00195. GTPase_Der. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR016484. GTP-bd_EngA. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR005225. Small_GTP-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
KO	K03977.
PANTHER	PTHR11649:SF5. PTHR11649:SF5. 1 hit.
Pfam	PF01926. MMR_HSR1. 2 hits. [Graphical view]
PIRSF	PIRSF006485. GTP-binding_EngA. 1 hit.
PRINTS	PR00326. GTP1OBG.
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR03594. GTPase_EngA. 1 hit. TIGR00231. Small_GTP. 2 hits.
ProtoNet	Search...

Entry information

Entry name

DER_MYCVP

Accession

Primary (citable) accession number: A1TA72

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program