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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei109 – 1091Transition state stabilizerUniRule annotation
Active sitei113 – 1131Proton acceptorUniRule annotation
Metal bindingi281 – 2811Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-3227-MONOMER.

Protein family/group databases

PeroxiBasei3576. MvaCP02_PYR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:Mvan_3208
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Catalase-peroxidase 1PRO_0000354847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki112 ↔ 240Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-266)UniRule annotation
Cross-linki240 ↔ 266Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-112)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_3208.

Structurei

3D structure databases

ProteinModelPortaliA1TA09.
SMRiA1TA09. Positions 40-746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiVVWTPTP.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TA09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTSDARPP HSDDKTRSHS ESENPAIDSP EPKVHAPLTN KDWWPEQVDV
60 70 80 90 100
SVLHKQNEKG NPLGEDFDYA TEFAKLDVEA FKRDVIDLIN TSQDWWPADY
110 120 130 140 150
GSYAGLFIRM SWHAAGTYRI FDGRGGAGQG SQRFAPLNSW PDNANLDKAR
160 170 180 190 200
RLLWPIKRKY GNKISWADLI AYAGNAALES AGFQTFGFAF GREDIWEPEE
210 220 230 240 250
MLWGQEDTWL GTDKRYGGTN DSDTRELAEP FGATTMGLIY VNPEGPEGKP
260 270 280 290 300
DPLAAAHDIR ETFGRMAMND EETAALIVGG HTLGKTHGAA DVNVGPEPEG
310 320 330 340 350
APIEQQGLGW KCPFGTGNAG DTVTSGLEVV WTTTPTKWSN AYLELLYGYE
360 370 380 390 400
WELTKSPGGA WQFEAKDAEA IIPDPFGGPP RKPTMLVTDV SMRVDPIYGP
410 420 430 440 450
ITRRWLDHPE EMNEAFAKAW YKLMHRDMGP VSRYLGPWVA EPQLWQDPVP
460 470 480 490 500
AVDHELIDES DIAALKAAVL QSGLSVPQLV KTAWASASSF RGTDKRGGAN
510 520 530 540 550
GARLRLEPQR SWEANEPSEL DKVLPVLERI QQDFNASATG GKKVSLADLI
560 570 580 590 600
VLAGSAAVEK AAKDGGYEIS VHFAPGRTDA SQEQTDVDSF AVLEPRADGF
610 620 630 640 650
RNFARPGEKT PLEQLLVDKA YFLDLTAPEM TALIGGLRTL NANHGGSKHG
660 670 680 690 700
VFTERPGVLS NDFFVNLLDM GTEWKPSELT ENVYDGKDRA TGQPKWTATA
710 720 730 740
ADLVFGSNSV LRAVVEVYAQ DDNQGKFVED FVAAWVKVMN NDRFDLG
Length:747
Mass (Da):82,208
Last modified:February 6, 2007 - v1
Checksum:iF081DB8AE9B70E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM14009.1.
RefSeqiWP_011780414.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM14009; ABM14009; Mvan_3208.
KEGGimva:Mvan_3208.
PATRICi18184693. VBIMycVan31953_3268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM14009.1.
RefSeqiWP_011780414.1. NC_008726.1.

3D structure databases

ProteinModelPortaliA1TA09.
SMRiA1TA09. Positions 40-746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_3208.

Protein family/group databases

PeroxiBasei3576. MvaCP02_PYR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM14009; ABM14009; Mvan_3208.
KEGGimva:Mvan_3208.
PATRICi18184693. VBIMycVan31953_3268.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiVVWTPTP.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-3227-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiKATG1_MYCVP
AccessioniPrimary (citable) accession number: A1TA09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: December 9, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.