Reviewed, UniProtKB/Swiss-Prot A1TA09 (KATG1_MYCVP)

Names and origin

Protein names

Recommended name:
    Catalase-peroxidase 1
      Short name=CP 1
    EC=1.11.1.6
    EC=1.11.1.7
Alternative name(s):
    Peroxidase/catalase 1

Gene names

Name:	katG1
Ordered Locus Names:	Mvan_3208

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity.
Catalytic activity	2 H2O2 = O2 + 2 H2O. HAMAP MF_01961 Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Homodimer or homotetramer By similarity.
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity.
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: HAMAP heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 747	747	Catalase-peroxidase 1 HAMAP MF_01961		PRO_0000354847
Sites
	Active site	113	1	Proton acceptor By similarity
	Metal binding	281	1	Iron (heme axial ligand) By similarity
	Site	109	1	Transition state stabilizer By similarity
Amino acid modifications
	Cross-link	112 ↔ 240		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-266) By similarity
	Cross-link	240 ↔ 266		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-112) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TA09-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F081DB8AE9B70E83	FASTA	747	82,208
	10 20 30 40 50 60 MTDTSDARPP HSDDKTRSHS ESENPAIDSP EPKVHAPLTN KDWWPEQVDV SVLHKQNEKG 70 80 90 100 110 120 NPLGEDFDYA TEFAKLDVEA FKRDVIDLIN TSQDWWPADY GSYAGLFIRM SWHAAGTYRI 130 140 150 160 170 180 FDGRGGAGQG SQRFAPLNSW PDNANLDKAR RLLWPIKRKY GNKISWADLI AYAGNAALES 190 200 210 220 230 240 AGFQTFGFAF GREDIWEPEE MLWGQEDTWL GTDKRYGGTN DSDTRELAEP FGATTMGLIY 250 260 270 280 290 300 VNPEGPEGKP DPLAAAHDIR ETFGRMAMND EETAALIVGG HTLGKTHGAA DVNVGPEPEG 310 320 330 340 350 360 APIEQQGLGW KCPFGTGNAG DTVTSGLEVV WTTTPTKWSN AYLELLYGYE WELTKSPGGA 370 380 390 400 410 420 WQFEAKDAEA IIPDPFGGPP RKPTMLVTDV SMRVDPIYGP ITRRWLDHPE EMNEAFAKAW 430 440 450 460 470 480 YKLMHRDMGP VSRYLGPWVA EPQLWQDPVP AVDHELIDES DIAALKAAVL QSGLSVPQLV 490 500 510 520 530 540 KTAWASASSF RGTDKRGGAN GARLRLEPQR SWEANEPSEL DKVLPVLERI QQDFNASATG 550 560 570 580 590 600 GKKVSLADLI VLAGSAAVEK AAKDGGYEIS VHFAPGRTDA SQEQTDVDSF AVLEPRADGF 610 620 630 640 650 660 RNFARPGEKT PLEQLLVDKA YFLDLTAPEM TALIGGLRTL NANHGGSKHG VFTERPGVLS 670 680 690 700 710 720 NDFFVNLLDM GTEWKPSELT ENVYDGKDRA TGQPKWTATA ADLVFGSNSV LRAVVEVYAQ 730 740 DDNQGKFVED FVAAWVKVMN NDRFDLG

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000511 Genomic DNA. Translation: ABM14009.1.
RefSeq	YP_954015.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TA09.
Genome annotation databases
GeneID	4648486.
GenomeReviews	Gene locus Mvan_3208 in contig CP000511_GR.
KEGG	mva:Mvan_3208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QGKFVED.
Family and domain databases
HAMAP	MF_01961. [Tree]
InterPro	IPR000763. Catalase_proxase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
TIGRFAMs	TIGR00198. cat_per_HPI. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KATG1_MYCVP

Accession

Primary (citable) accession number: A1TA09

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)