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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei109Transition state stabilizerUniRule annotation1
Active sitei113Proton acceptorUniRule annotation1
Metal bindingi281Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-3239-MONOMER

Protein family/group databases

PeroxiBasei3576 MvaCP02_PYR1

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:Mvan_3208
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548471 – 747Catalase-peroxidase 1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112 ↔ 240Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-266)UniRule annotation
Cross-linki240 ↔ 266Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-112)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1TA09

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_3208

Structurei

3D structure databases

ProteinModelPortaliA1TA09
SMRiA1TA09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiEPEEIFW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 2 hits

Sequencei

Sequence statusi: Complete.

A1TA09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTSDARPP HSDDKTRSHS ESENPAIDSP EPKVHAPLTN KDWWPEQVDV
60 70 80 90 100
SVLHKQNEKG NPLGEDFDYA TEFAKLDVEA FKRDVIDLIN TSQDWWPADY
110 120 130 140 150
GSYAGLFIRM SWHAAGTYRI FDGRGGAGQG SQRFAPLNSW PDNANLDKAR
160 170 180 190 200
RLLWPIKRKY GNKISWADLI AYAGNAALES AGFQTFGFAF GREDIWEPEE
210 220 230 240 250
MLWGQEDTWL GTDKRYGGTN DSDTRELAEP FGATTMGLIY VNPEGPEGKP
260 270 280 290 300
DPLAAAHDIR ETFGRMAMND EETAALIVGG HTLGKTHGAA DVNVGPEPEG
310 320 330 340 350
APIEQQGLGW KCPFGTGNAG DTVTSGLEVV WTTTPTKWSN AYLELLYGYE
360 370 380 390 400
WELTKSPGGA WQFEAKDAEA IIPDPFGGPP RKPTMLVTDV SMRVDPIYGP
410 420 430 440 450
ITRRWLDHPE EMNEAFAKAW YKLMHRDMGP VSRYLGPWVA EPQLWQDPVP
460 470 480 490 500
AVDHELIDES DIAALKAAVL QSGLSVPQLV KTAWASASSF RGTDKRGGAN
510 520 530 540 550
GARLRLEPQR SWEANEPSEL DKVLPVLERI QQDFNASATG GKKVSLADLI
560 570 580 590 600
VLAGSAAVEK AAKDGGYEIS VHFAPGRTDA SQEQTDVDSF AVLEPRADGF
610 620 630 640 650
RNFARPGEKT PLEQLLVDKA YFLDLTAPEM TALIGGLRTL NANHGGSKHG
660 670 680 690 700
VFTERPGVLS NDFFVNLLDM GTEWKPSELT ENVYDGKDRA TGQPKWTATA
710 720 730 740
ADLVFGSNSV LRAVVEVYAQ DDNQGKFVED FVAAWVKVMN NDRFDLG
Length:747
Mass (Da):82,208
Last modified:February 6, 2007 - v1
Checksum:iF081DB8AE9B70E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM14009.1
RefSeqiWP_011780414.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM14009; ABM14009; Mvan_3208
KEGGimva:Mvan_3208

Similar proteinsi

Entry informationi

Entry nameiKATG1_MYCVP
AccessioniPrimary (citable) accession number: A1TA09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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