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A1T9P9

- MASZ_MYCVP

UniProt

A1T9P9 - MASZ_MYCVP

Protein

Malate synthase G

Gene

glcB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Binding sitei276 – 2761Acetyl-CoAUniRule annotation
    Binding sitei313 – 3131Acetyl-CoAUniRule annotation
    Active sitei345 – 3451Proton acceptorUniRule annotation
    Binding sitei345 – 3451GlyoxylateUniRule annotation
    Metal bindingi440 – 4401MagnesiumUniRule annotation
    Binding sitei440 – 4401GlyoxylateUniRule annotation
    Metal bindingi468 – 4681MagnesiumUniRule annotation
    Binding sitei549 – 5491Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Active sitei639 – 6391Proton donorUniRule annotation

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-HAMAP
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-3116-MONOMER.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
    Gene namesi
    Name:glcBUniRule annotation
    Ordered Locus Names:Mvan_3097
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 734734Malate synthase GPRO_1000056912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei625 – 6251Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi350058.Mvan_3097.

    Structurei

    3D structure databases

    ProteinModelPortaliA1T9P9.
    SMRiA1T9P9. Positions 5-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
    Regioni465 – 4684Glyoxylate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000220740.
    KOiK01638.
    OMAiSTIMDFE.
    OrthoDBiEOG6HJ286.

    Family and domain databases

    Gene3Di2.170.170.11. 2 hits.
    HAMAPiMF_00641. Malate_synth_G.
    InterProiIPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1T9P9-1 [UniParc]FASTAAdd to Basket

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    MTDRVTVGNL RVAPVLYDFI NNEALPGTDI DPDTFWSGVD KVVADLTPRN    50
    QDLLARRDDL QAQIDRWHRA RVIGGFEPED YKQFLTDIGY LEPEPADFSI 100
    TTAGVDDEIT TTAGPQLVVP ILNARFALNA ANARWGSLYD ALYGTDVISD 150
    EGGAEAGSGY NPVRGDKVIA YARRFLDGAV PLASGSWSDI TGLKLDEGQL 200
    AATLDDGGTV GLGTPEQFVG YLGDAEAPTA VLLVNNGLHI EILIDAEAPI 250
    GATDKAGIKD VVLESAITTI MDFEDSVAAV DADDKVLGYR NWLGLNRGDL 300
    AEEVSKGGKT FTRVLNSDRT YTAANPGPDG ATELTLPGRS LLFVRNVGHL 350
    MTNDAIVDAQ GNEIPEGIQD ALFTSLIGIH GLRTGDGNGP LVNSRTGSIY 400
    IVKPKMHGPD EVAFTCELFS RVEDVLGLPQ NTLKVGIMDE ERRTTLNLKA 450
    CIKAAADRVV FINTGFLDRT GDEIHTSMDA GPMIRKGAMK STEWIAAYEN 500
    QNVDIGLETG FSGRAQIGKG MWAMTDLMAD MVEQKIGQPR AGATTAWVPS 550
    PTAATLHAMH YHEVDVFAVH NELAGTRRGT VDQLLTIPLA KELAWAPEEI 600
    REEVDNNCQS ILGYVVRWID AGVGCSKVPD IHDVALMEDR ATLRISSQLL 650
    ANWLRHGVIT EEDVKASLRR MAAVVDEQNA ADPDFRPMAP DPDGSIAFQA 700
    AQELILSGAD QPNGYTEPIL HRRRREFKAA SNVG 734
    Length:734
    Mass (Da):79,327
    Last modified:February 6, 2007 - v1
    Checksum:i8A57EC7050B20332
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM13899.1.
    RefSeqiYP_953905.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM13899; ABM13899; Mvan_3097.
    GeneIDi4646853.
    KEGGimva:Mvan_3097.
    PATRICi18184465. VBIMycVan31953_3154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM13899.1 .
    RefSeqi YP_953905.1. NC_008726.1.

    3D structure databases

    ProteinModelPortali A1T9P9.
    SMRi A1T9P9. Positions 5-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_3097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM13899 ; ABM13899 ; Mvan_3097 .
    GeneIDi 4646853.
    KEGGi mva:Mvan_3097.
    PATRICi 18184465. VBIMycVan31953_3154.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000220740.
    KOi K01638.
    OMAi STIMDFE.
    OrthoDBi EOG6HJ286.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BioCyci MVAN350058:GIWR-3116-MONOMER.

    Family and domain databases

    Gene3Di 2.170.170.11. 2 hits.
    HAMAPi MF_00641. Malate_synth_G.
    InterProi IPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiMASZ_MYCVP
    AccessioniPrimary (citable) accession number: A1T9P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3