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A1T9P9

- MASZ_MYCVP

UniProt

A1T9P9 - MASZ_MYCVP

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Protein

Malate synthase G

Gene
glcB, Mvan_3097
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei276 – 2761Acetyl-CoA By similarity
Binding sitei313 – 3131Acetyl-CoA By similarity
Active sitei345 – 3451Proton acceptor By similarity
Binding sitei345 – 3451Glyoxylate By similarity
Metal bindingi440 – 4401Magnesium By similarity
Binding sitei440 – 4401Glyoxylate By similarity
Metal bindingi468 – 4681Magnesium By similarity
Binding sitei549 – 5491Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei639 – 6391Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-3116-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Mvan_3097
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 734734Malate synthase GUniRule annotationPRO_1000056912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_3097.

Structurei

3D structure databases

ProteinModelPortaliA1T9P9.
SMRiA1T9P9. Positions 5-729.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni465 – 4684Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSTIMDFE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A1T9P9-1 [UniParc]FASTAAdd to Basket

« Hide

MTDRVTVGNL RVAPVLYDFI NNEALPGTDI DPDTFWSGVD KVVADLTPRN    50
QDLLARRDDL QAQIDRWHRA RVIGGFEPED YKQFLTDIGY LEPEPADFSI 100
TTAGVDDEIT TTAGPQLVVP ILNARFALNA ANARWGSLYD ALYGTDVISD 150
EGGAEAGSGY NPVRGDKVIA YARRFLDGAV PLASGSWSDI TGLKLDEGQL 200
AATLDDGGTV GLGTPEQFVG YLGDAEAPTA VLLVNNGLHI EILIDAEAPI 250
GATDKAGIKD VVLESAITTI MDFEDSVAAV DADDKVLGYR NWLGLNRGDL 300
AEEVSKGGKT FTRVLNSDRT YTAANPGPDG ATELTLPGRS LLFVRNVGHL 350
MTNDAIVDAQ GNEIPEGIQD ALFTSLIGIH GLRTGDGNGP LVNSRTGSIY 400
IVKPKMHGPD EVAFTCELFS RVEDVLGLPQ NTLKVGIMDE ERRTTLNLKA 450
CIKAAADRVV FINTGFLDRT GDEIHTSMDA GPMIRKGAMK STEWIAAYEN 500
QNVDIGLETG FSGRAQIGKG MWAMTDLMAD MVEQKIGQPR AGATTAWVPS 550
PTAATLHAMH YHEVDVFAVH NELAGTRRGT VDQLLTIPLA KELAWAPEEI 600
REEVDNNCQS ILGYVVRWID AGVGCSKVPD IHDVALMEDR ATLRISSQLL 650
ANWLRHGVIT EEDVKASLRR MAAVVDEQNA ADPDFRPMAP DPDGSIAFQA 700
AQELILSGAD QPNGYTEPIL HRRRREFKAA SNVG 734
Length:734
Mass (Da):79,327
Last modified:February 6, 2007 - v1
Checksum:i8A57EC7050B20332
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13899.1.
RefSeqiYP_953905.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13899; ABM13899; Mvan_3097.
GeneIDi4646853.
KEGGimva:Mvan_3097.
PATRICi18184465. VBIMycVan31953_3154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13899.1 .
RefSeqi YP_953905.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T9P9.
SMRi A1T9P9. Positions 5-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_3097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM13899 ; ABM13899 ; Mvan_3097 .
GeneIDi 4646853.
KEGGi mva:Mvan_3097.
PATRICi 18184465. VBIMycVan31953_3154.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi STIMDFE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci MVAN350058:GIWR-3116-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiMASZ_MYCVP
AccessioniPrimary (citable) accession number: A1T9P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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