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A1T9P9

- MASZ_MYCVP

UniProt

A1T9P9 - MASZ_MYCVP

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Protein

Malate synthase G

Gene

glcB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei276 – 2761Acetyl-CoAUniRule annotation
Binding sitei313 – 3131Acetyl-CoAUniRule annotation
Active sitei345 – 3451Proton acceptorUniRule annotation
Binding sitei345 – 3451GlyoxylateUniRule annotation
Metal bindingi440 – 4401MagnesiumUniRule annotation
Binding sitei440 – 4401GlyoxylateUniRule annotation
Metal bindingi468 – 4681MagnesiumUniRule annotation
Binding sitei549 – 5491Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei639 – 6391Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-3116-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Mvan_3097
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 734734Malate synthase GPRO_1000056912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_3097.

Structurei

3D structure databases

ProteinModelPortaliA1T9P9.
SMRiA1T9P9. Positions 5-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni465 – 4684Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSTIMDFE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A1T9P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDRVTVGNL RVAPVLYDFI NNEALPGTDI DPDTFWSGVD KVVADLTPRN
60 70 80 90 100
QDLLARRDDL QAQIDRWHRA RVIGGFEPED YKQFLTDIGY LEPEPADFSI
110 120 130 140 150
TTAGVDDEIT TTAGPQLVVP ILNARFALNA ANARWGSLYD ALYGTDVISD
160 170 180 190 200
EGGAEAGSGY NPVRGDKVIA YARRFLDGAV PLASGSWSDI TGLKLDEGQL
210 220 230 240 250
AATLDDGGTV GLGTPEQFVG YLGDAEAPTA VLLVNNGLHI EILIDAEAPI
260 270 280 290 300
GATDKAGIKD VVLESAITTI MDFEDSVAAV DADDKVLGYR NWLGLNRGDL
310 320 330 340 350
AEEVSKGGKT FTRVLNSDRT YTAANPGPDG ATELTLPGRS LLFVRNVGHL
360 370 380 390 400
MTNDAIVDAQ GNEIPEGIQD ALFTSLIGIH GLRTGDGNGP LVNSRTGSIY
410 420 430 440 450
IVKPKMHGPD EVAFTCELFS RVEDVLGLPQ NTLKVGIMDE ERRTTLNLKA
460 470 480 490 500
CIKAAADRVV FINTGFLDRT GDEIHTSMDA GPMIRKGAMK STEWIAAYEN
510 520 530 540 550
QNVDIGLETG FSGRAQIGKG MWAMTDLMAD MVEQKIGQPR AGATTAWVPS
560 570 580 590 600
PTAATLHAMH YHEVDVFAVH NELAGTRRGT VDQLLTIPLA KELAWAPEEI
610 620 630 640 650
REEVDNNCQS ILGYVVRWID AGVGCSKVPD IHDVALMEDR ATLRISSQLL
660 670 680 690 700
ANWLRHGVIT EEDVKASLRR MAAVVDEQNA ADPDFRPMAP DPDGSIAFQA
710 720 730
AQELILSGAD QPNGYTEPIL HRRRREFKAA SNVG
Length:734
Mass (Da):79,327
Last modified:February 6, 2007 - v1
Checksum:i8A57EC7050B20332
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13899.1.
RefSeqiYP_953905.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13899; ABM13899; Mvan_3097.
GeneIDi4646853.
KEGGimva:Mvan_3097.
PATRICi18184465. VBIMycVan31953_3154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13899.1 .
RefSeqi YP_953905.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T9P9.
SMRi A1T9P9. Positions 5-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_3097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM13899 ; ABM13899 ; Mvan_3097 .
GeneIDi 4646853.
KEGGi mva:Mvan_3097.
PATRICi 18184465. VBIMycVan31953_3154.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi STIMDFE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci MVAN350058:GIWR-3116-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiMASZ_MYCVP
AccessioniPrimary (citable) accession number: A1T9P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3