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A1T9L9

- MDH_MYCVP

UniProt

A1T9L9 - MDH_MYCVP

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Protein
Malate dehydrogenase
Gene
mdh, Mvan_3067
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961Substrate By similarity
Binding sitei102 – 1021Substrate By similarity
Binding sitei109 – 1091NAD By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Active sitei191 – 1911Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 217NAD By similarity
Nucleotide bindingi133 – 1353NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-3086-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Mvan_3067
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Malate dehydrogenaseUniRule annotation
PRO_0000292373Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_3067.

Structurei

3D structure databases

ProteinModelPortaliA1T9L9.
SMRiA1T9L9. Positions 6-332.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiFPDYRHA.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

A1T9L9-1 [UniParc]FASTAAdd to Basket

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MSSTTASPVT VAVTGAAGHI GYAALFRIAA GAMLGHTTPV TLRLLELPDA    50
VRAAEGVVME LEDGAFPLLA GTEIYDDPTR AFDGVDVALL IGARPRTKGM 100
ERADLLGANA EIFATSGKAL NAGASPDVRV LVVGNPANTN ALVASAHAPD 150
IPADRFTALT RLDHNRAVAA TARHSGVPVT EISRMTIWGN HSPTQYPDIF 200
HAVVGGRSGA DYAADTRWLT DDFIPTVARR GTAIIEARGA SSAASAANGA 250
IDHIDDWVHG TPDGDWTSVA LPSPGAYGVD EGLVCSFPCR SVGGRWEIVE 300
GLDINPFSRA RIDASVAELR TERDAVAALG LL 332
Length:332
Mass (Da):34,506
Last modified:February 6, 2007 - v1
Checksum:i318F708372599FB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13869.1.
RefSeqiWP_011780274.1. NC_008726.1.
YP_953875.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13869; ABM13869; Mvan_3067.
GeneIDi4646973.
KEGGimva:Mvan_3067.
PATRICi18184407. VBIMycVan31953_3125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13869.1 .
RefSeqi WP_011780274.1. NC_008726.1.
YP_953875.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T9L9.
SMRi A1T9L9. Positions 6-332.
ModBasei Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_3067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM13869 ; ABM13869 ; Mvan_3067 .
GeneIDi 4646973.
KEGGi mva:Mvan_3067.
PATRICi 18184407. VBIMycVan31953_3125.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi FPDYRHA.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-3086-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiMDH_MYCVP
AccessioniPrimary (citable) accession number: A1T9L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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