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A1T9L9

- MDH_MYCVP

UniProt

A1T9L9 - MDH_MYCVP

Protein

Malate dehydrogenase

Gene

mdh

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961SubstrateUniRule annotation
    Binding sitei102 – 1021SubstrateUniRule annotation
    Binding sitei109 – 1091NADUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Active sitei191 – 1911Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 217NADUniRule annotation
    Nucleotide bindingi133 – 1353NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-3086-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Mvan_3067
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Malate dehydrogenasePRO_0000292373Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi350058.Mvan_3067.

    Structurei

    3D structure databases

    ProteinModelPortaliA1T9L9.
    SMRiA1T9L9. Positions 6-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiFPDYRHA.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1T9L9-1 [UniParc]FASTAAdd to Basket

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    MSSTTASPVT VAVTGAAGHI GYAALFRIAA GAMLGHTTPV TLRLLELPDA    50
    VRAAEGVVME LEDGAFPLLA GTEIYDDPTR AFDGVDVALL IGARPRTKGM 100
    ERADLLGANA EIFATSGKAL NAGASPDVRV LVVGNPANTN ALVASAHAPD 150
    IPADRFTALT RLDHNRAVAA TARHSGVPVT EISRMTIWGN HSPTQYPDIF 200
    HAVVGGRSGA DYAADTRWLT DDFIPTVARR GTAIIEARGA SSAASAANGA 250
    IDHIDDWVHG TPDGDWTSVA LPSPGAYGVD EGLVCSFPCR SVGGRWEIVE 300
    GLDINPFSRA RIDASVAELR TERDAVAALG LL 332
    Length:332
    Mass (Da):34,506
    Last modified:February 6, 2007 - v1
    Checksum:i318F708372599FB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM13869.1.
    RefSeqiWP_011780274.1. NC_008726.1.
    YP_953875.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM13869; ABM13869; Mvan_3067.
    GeneIDi4646973.
    KEGGimva:Mvan_3067.
    PATRICi18184407. VBIMycVan31953_3125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM13869.1 .
    RefSeqi WP_011780274.1. NC_008726.1.
    YP_953875.1. NC_008726.1.

    3D structure databases

    ProteinModelPortali A1T9L9.
    SMRi A1T9L9. Positions 6-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_3067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM13869 ; ABM13869 ; Mvan_3067 .
    GeneIDi 4646973.
    KEGGi mva:Mvan_3067.
    PATRICi 18184407. VBIMycVan31953_3125.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi FPDYRHA.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci MVAN350058:GIWR-3086-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiMDH_MYCVP
    AccessioniPrimary (citable) accession number: A1T9L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3