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Protein

Malate dehydrogenase

Gene

mdh

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96SubstrateUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Binding sitei109NADUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei166SubstrateUniRule annotation1
Active sitei191Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 21NADUniRule annotation7
Nucleotide bindingi133 – 135NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-3099-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Mvan_3067
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002923731 – 332Malate dehydrogenaseAdd BLAST332

Proteomic databases

PRIDEiA1T9L9

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_3067

Structurei

3D structure databases

ProteinModelPortaliA1T9L9
SMRiA1T9L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

A1T9L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTTASPVT VAVTGAAGHI GYAALFRIAA GAMLGHTTPV TLRLLELPDA
60 70 80 90 100
VRAAEGVVME LEDGAFPLLA GTEIYDDPTR AFDGVDVALL IGARPRTKGM
110 120 130 140 150
ERADLLGANA EIFATSGKAL NAGASPDVRV LVVGNPANTN ALVASAHAPD
160 170 180 190 200
IPADRFTALT RLDHNRAVAA TARHSGVPVT EISRMTIWGN HSPTQYPDIF
210 220 230 240 250
HAVVGGRSGA DYAADTRWLT DDFIPTVARR GTAIIEARGA SSAASAANGA
260 270 280 290 300
IDHIDDWVHG TPDGDWTSVA LPSPGAYGVD EGLVCSFPCR SVGGRWEIVE
310 320 330
GLDINPFSRA RIDASVAELR TERDAVAALG LL
Length:332
Mass (Da):34,506
Last modified:February 6, 2007 - v1
Checksum:i318F708372599FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM13869.1
RefSeqiWP_011780274.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM13869; ABM13869; Mvan_3067
KEGGimva:Mvan_3067

Similar proteinsi

Entry informationi

Entry nameiMDH_MYCVP
AccessioniPrimary (citable) accession number: A1T9L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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