Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104Transition state stabilizerUniRule annotation1
Active sitei108Proton acceptorUniRule annotation1
Metal bindingi276Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:Mvan_2984
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548481 – 737Catalase-peroxidase 2Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki107 ↔ 235Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-261)UniRule annotation
Cross-linki235 ↔ 261Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_2984.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiLINDPEY.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1T9D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEATEHPPI GEAQTEPAQS GCPMVIKPPV EGGSNRDWWP NAVNLKMLQK
60 70 80 90 100
DPEVIDPMDE GYDYREAVQT LDVDQLARDF DELCTNSQDW WPADFGHYGP
110 120 130 140 150
LFIRMSWHAA GTYRVQDGRG GAGKGMQRFA PLNSWPDNVS LDKARRLLWP
160 170 180 190 200
LKKKYGKKLS WSDLIVYAGN RAMENMGFKT AGFAFGRPDY WEPEEDVYWG
210 220 230 240 250
AEHEWLGSQD RYAGANGDRT KLENPLGASH MGLIYVNPEG PEGNPDPIAA
260 270 280 290 300
AIDIRETFGR MAMNDVETAA LIVGGHTFGK THGATDIVNG PEPEAAPLEQ
310 320 330 340 350
MGLGWSNPGV GIDTVSSGLE VTWTHTPTKW DNSFLEILYG NEWELFKSPA
360 370 380 390 400
GANQWRPKDN GWANSVPMAQ GTGKTHPAML TTDLSMRMDP IYGEITRRWL
410 420 430 440 450
DHPEELAEEY AKAWFKLLHR DMGPVQRYLG PLVPTQTWLW QDIVPAGKPL
460 470 480 490 500
SDADVATLKG AIADSGLTVQ QLVSTAWKAA SSFRISDMRG GANGGRIRLQ
510 520 530 540 550
PQLGWESNEP DELAQVISKL EEIQGSSGID VSFADLVVLG GNVGIETAAK
560 570 580 590 600
AAGFDIEVPF SSGRGDATQE QTDVEAFSYL EPKADGFRNY VGKGLNLPAE
610 620 630 640 650
YQLIDQANLL NLSAPQMTVL IGGLRALGIT HGDSKLGVLT DTPGQLTNDY
660 670 680 690 700
FVNLTDMGVK WAPAPADDGT YVGTDRDTGE VKYTASRVDL LFGSNSQLRA
710 720 730
LAEVYAEDDS RDKFVKDFVA AWVNVMDADR YDIGKGA
Length:737
Mass (Da):80,850
Last modified:February 6, 2007 - v1
Checksum:iD628D8A6B2FA46F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13789.1.
RefSeqiWP_011780194.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13789; ABM13789; Mvan_2984.
KEGGimva:Mvan_2984.
PATRICi18184241. VBIMycVan31953_3042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13789.1.
RefSeqiWP_011780194.1. NC_008726.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_2984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM13789; ABM13789; Mvan_2984.
KEGGimva:Mvan_2984.
PATRICi18184241. VBIMycVan31953_3042.

Phylogenomic databases

eggNOGiCOG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiLINDPEY.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_MYCVP
AccessioniPrimary (citable) accession number: A1T9D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.