A1T9D9 (KATG2_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase-peroxidase 2
Short name=CP 2
EC=1.11.1.21

Alternative name(s):
Peroxidase/catalase 2

Gene names

Name:	katG2
Ordered Locus Names:	Mvan_2984

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	737 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 2 H2O2 = O2 + 2 H2O. HAMAP MF_01961
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 737	737	Catalase-peroxidase 2 HAMAP MF_01961		PRO_0000354848
Sites
	Active site	108	1	Proton acceptor By similarity
	Metal binding	276	1	Iron (heme axial ligand) By similarity
	Site	104	1	Transition state stabilizer By similarity
Amino acid modifications
	Cross-link	107 ↔ 235		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-261) By similarity
	Cross-link	235 ↔ 261		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1T9D9 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: D628D8A6B2FA46F3	FASTA	737	80,850
	10 20 30 40 50 60 MPEATEHPPI GEAQTEPAQS GCPMVIKPPV EGGSNRDWWP NAVNLKMLQK DPEVIDPMDE 70 80 90 100 110 120 GYDYREAVQT LDVDQLARDF DELCTNSQDW WPADFGHYGP LFIRMSWHAA GTYRVQDGRG 130 140 150 160 170 180 GAGKGMQRFA PLNSWPDNVS LDKARRLLWP LKKKYGKKLS WSDLIVYAGN RAMENMGFKT 190 200 210 220 230 240 AGFAFGRPDY WEPEEDVYWG AEHEWLGSQD RYAGANGDRT KLENPLGASH MGLIYVNPEG 250 260 270 280 290 300 PEGNPDPIAA AIDIRETFGR MAMNDVETAA LIVGGHTFGK THGATDIVNG PEPEAAPLEQ 310 320 330 340 350 360 MGLGWSNPGV GIDTVSSGLE VTWTHTPTKW DNSFLEILYG NEWELFKSPA GANQWRPKDN 370 380 390 400 410 420 GWANSVPMAQ GTGKTHPAML TTDLSMRMDP IYGEITRRWL DHPEELAEEY AKAWFKLLHR 430 440 450 460 470 480 DMGPVQRYLG PLVPTQTWLW QDIVPAGKPL SDADVATLKG AIADSGLTVQ QLVSTAWKAA 490 500 510 520 530 540 SSFRISDMRG GANGGRIRLQ PQLGWESNEP DELAQVISKL EEIQGSSGID VSFADLVVLG 550 560 570 580 590 600 GNVGIETAAK AAGFDIEVPF SSGRGDATQE QTDVEAFSYL EPKADGFRNY VGKGLNLPAE 610 620 630 640 650 660 YQLIDQANLL NLSAPQMTVL IGGLRALGIT HGDSKLGVLT DTPGQLTNDY FVNLTDMGVK 670 680 690 700 710 720 WAPAPADDGT YVGTDRDTGE VKYTASRVDL LFGSNSQLRA LAEVYAEDDS RDKFVKDFVA 730 AWVNVMDADR YDIGKGA

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM13789.1.
RefSeq	YP_953795.1. NC_008726.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1T9D9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000080407; EBMYCP00000078360; EBMYCG00000080402.
GeneID	4645112.
GenomeReviews	Gene locus Mvan_2984 in contig CP000511_GR.
KEGG	mva:Mvan_2984.
PATRIC	18184241. VBIMycVan31953_3042.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0376.
GeneTree	EBGT00050000017549.
HOGENOM	HBG285610.
OMA	GWANSVP.
PhylomeDB	A1T9D9.
ProtClustDB	PRK15061.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_2984-MONOMER.
Family and domain databases
HAMAP	MF_01961. Catal-peroxid. [Tree]
InterPro	IPR000763. Catalase_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
TIGRFAMs	TIGR00198. Cat_per_HPI. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KATG2_MYCVP

Accession

Primary (citable) accession number: A1T9D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program