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A1T8G8 (A1T8G8_MYCVP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:Mvan_2661
OrganismMycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]
Taxonomic identifier350058 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
A1T8G8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 28342D2B3EADDC1D

FASTA44246,620
        10         20         30         40         50         60 
MTSSSPESLR SCPPIVLKSV RLYGEGDPVD VLVRDGQIAE IGERLTAPTD ADSIDCEGKI 

        70         80         90        100        110        120 
LLPGFVDLHT HLREPGREYA EDIETGSAAA ALGGYTAVFA MANTDPVADS AVVTDHVWHR 

       130        140        150        160        170        180 
GQQVGLVDVH PVGAVTVGLD GKQLTEMGLM AAGAGQVRMF SDDGVCVDDP LVMRRALEYA 

       190        200        210        220        230        240 
SGLGVLIAQH AEEPRLTVGA VAHEGPNAAR LGLAGWPRAA EESIVARDAL LARDAGARVH 

       250        260        270        280        290        300 
ICHASTAGTV ELLKWAKSQG ISITAEVTPH HLLLDDSRLD TYDGVNRVNP PLREVSDAVA 

       310        320        330        340        350        360 
LRRALADGVI DCVATDHAPH GAHEKCCEFA NARPGMLGLQ TALSVVVETL VNPGLLTWRD 

       370        380        390        400        410        420 
VARVMSEAPA RIVGLPDQGR PLEVGEPANL TVVDPAARWT VKGPELASRS DNTPYEDMEL 

       430        440 
PAVVTATLLR GKVTARDGKV GA

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References

[1]"Complete sequence of Mycobacterium vanbaalenii PYR-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000511 Genomic DNA. Translation: ABM13468.1.
RefSeqYP_953474.1. NC_008726.1.

3D structure databases

ProteinModelPortalA1T8G8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1T8G8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000079609; EBMYCP00000077562; EBMYCG00000079604.
GeneID4644004.
GenomeReviewsGene locus Mvan_2661 in contig CP000511_GR.
KEGGmva:Mvan_2661.
PATRIC18183587. VBIMycVan31953_2716.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0044.
GeneTreeEBGT00050000016208.
HOGENOMHBG724623.
OMACDVHPVG.
PhylomeDBA1T8G8.
ProtClustDBPRK09357.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1T8G8_MYCVP
AccessionPrimary (citable) accession number: A1T8G8
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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