A1T8G7 (PYRB_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Mvan_2660

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301594

Sequences

	Sequence		Length	Mass (Da)
	A1T8G7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8BAACE9725DF7EA4	FASTA	315	33,812
	10 20 30 40 50 60 MKHLLTAADL SREDATAILD NADRFREALV GREVKKLPTL RGRTIITMFY ENSTRTRVSF 70 80 90 100 110 120 EVAGKWMSAD VINVSSSGSS VAKGESLRDT ALTLRAAGAD ALIIRHPASG AAQQLAAWTL 130 140 150 160 170 180 DEHGGPSIIN AGDGTHEHPT QALLDALTIR QRLGSVEGKR VVIVGDVLHS RVARSNVALL 190 200 210 220 230 240 HTLGAEVVLV APPTLLPVGV ADWPVTVSQD IDAELPLADA VLMLRVQAER MNGGFFPSSR 250 260 270 280 290 300 EYSVRYGLSE KRQSRLAEHA VVLHPGPMLR GMEIAYSVAD SSQSAVLQQV SNGVHVRMAV 310 LFHLLVGSEQ EAISA

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM13467.1.
RefSeq	YP_953473.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1T8G7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1T8G7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000080505; EBMYCP00000078458; EBMYCG00000080500.
GeneID	4644003.
GenomeReviews	Gene locus Mvan_2660 in contig CP000511_GR.
KEGG	mva:Mvan_2660.
PATRIC	18183585. VBIMycVan31953_2715.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000016463.
HOGENOM	HBG579429.
OMA	LQRERMS.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_2660-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_MYCVP

Accession

Primary (citable) accession number: A1T8G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program