A1T7N8 (DAPB_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Mvan_2374

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]

Taxonomic identifier

350058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008603

Sequences

	Sequence		Length	Mass (Da)
	A1T7N8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 890DD8A552C1D84A	FASTA	245	25,832
	10 20 30 40 50 60 MRVGVLGARG KVGATMVAGV EAADDLTFTT GVDAGDSLSA LVDSDTEVVI DFTHPSVVMD 70 80 90 100 110 120 NLKFLIDNGI HAVVGTTGFT DERLDQVREW LAATPGASVL IAPNFAIGAV LSMHFAQQAA 130 140 150 160 170 180 KYFESVEVIE LHHPHKADAP SGTAMRTARL IAEARKGMPP NPDATSTGLD GARGADVDGV 190 200 210 220 230 240 PVHSVRLAGL VAHQEVLFGT MGETLTIRHD SIDRTSFVPG VLLAVRKIRE RPGLTIGIEP LLDLK

References

[1]

"Complete sequence of Mycobacterium vanbaalenii PYR-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000511 Genomic DNA. Translation: ABM13188.1.
RefSeq	YP_953194.1. NC_008726.1.
3D structure databases
ProteinModelPortal	A1T7N8.
SMR	A1T7N8. Positions 1-244.
ModBase	Search...
Protein-protein interaction databases
STRING	A1T7N8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000079065; EBMYCP00000077018; EBMYCG00000079060.
GeneID	4644571.
GenomeReviews	Gene locus Mvan_2374 in contig CP000511_GR.
KEGG	mva:Mvan_2374.
PATRIC	18183003. VBIMycVan31953_2428.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
GeneTree	EBGT00050000017074.
HOGENOM	HBG594002.
OMA	DRASFMP.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	MVAN350058:MVAN_2374-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_MYCVP

Accession

Primary (citable) accession number: A1T7N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program