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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi525MagnesiumUniRule annotation1
Metal bindingi531MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-2375-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Mvan_2350
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297271 – 754Polyribonucleotide nucleotidyltransferaseAdd BLAST754

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2350

Structurei

3D structure databases

ProteinModelPortaliA1T7L4
SMRiA1T7L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini591 – 650KHUniRule annotationAdd BLAST60
Domaini662 – 731S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR014069 GPSI/PNP
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
TIGR02696 pppGpp_PNP, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A1T7L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVEIEDGV FESTATIDNG SFGTRTIRFE AGRLAQQAAG AVVAYLDDET
60 70 80 90 100
MLLSATTASK SPKEHFDFFP LTIDVEERMY AAGRIPGSFF RREGRPSTDA
110 120 130 140 150
ILTCRLIDRP LRPSFVSGLR NEIQVVVTVL SLDPKDLYDV LAINAASAST
160 170 180 190 200
QISGLPFSGP VGGVRVALID GQWVAFPTVE QLERAVFDMV VAGRKVGDDH
210 220 230 240 250
KDVAIMMVEA EATENVIELV AGGAGAPTET VVAEGLEAAK PFIAVLCDAQ
260 270 280 290 300
AALAGAAGKE TAEYPLFPDY GDDVYYSVAS VATEALSEAL TIAGKNERND
310 320 330 340 350
RTDEIKVEVL NRLAEQYAGR EKEIGAAYRS LTKKLVRQRI LTDHFRIDGR
360 370 380 390 400
GVTDIRALSA EVAVVPRAHG SALFERGETQ IMGVTTLDMV KMAQQIDSLG
410 420 430 440 450
PETSKRYMHH YNFPPYSTGE TGRVGSPKRR EIGHGALAER ALVPVLPSVE
460 470 480 490 500
EFPYAIRQVS EALGSNGSTS MGSVCASTLS LLNAGVPLKA PVAGIAMGLV
510 520 530 540 550
SDDIEIDGKT ERRFVTLTDI LGAEDAFGDM DFKCAGTKDF VTALQLDTKL
560 570 580 590 600
DGIPSQVLAG ALAQAKDARI TILEVMAEAI DTPDEMSPYA PRITTIKVPV
610 620 630 640 650
DKIGEVIGPK GKMINSITEE TGASISIEDD GTVFVGASNG EAAQAAIDKI
660 670 680 690 700
NAIANPQLPK VGERFLGTVV KTTDFGAFVS LLPGRDGLVH ISKLGRGKRI
710 720 730 740 750
NKVEDVAKVG DKLRVEIADI DNRGKISLVL VAEESETAAD APADAPVDAA

TTSS
Length:754
Mass (Da):80,173
Last modified:February 6, 2007 - v1
Checksum:i8CEF566CB7A92801
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM13164.1
RefSeqiWP_011779576.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM13164; ABM13164; Mvan_2350
KEGGimva:Mvan_2350

Similar proteinsi

Entry informationi

Entry nameiPNP_MYCVP
AccessioniPrimary (citable) accession number: A1T7L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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