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A1T7L4

- PNP_MYCVP

UniProt

A1T7L4 - PNP_MYCVP

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Mvan_2350
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi525 – 5251Magnesium By similarity
Metal bindingi531 – 5311Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-2364-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Mvan_2350
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329727Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2350.

Structurei

3D structure databases

ProteinModelPortaliA1T7L4.
SMRiA1T7L4. Positions 13-725.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini591 – 65060KH
Add
BLAST
Domaini662 – 73170S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1T7L4-1 [UniParc]FASTAAdd to Basket

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MSVVEIEDGV FESTATIDNG SFGTRTIRFE AGRLAQQAAG AVVAYLDDET    50
MLLSATTASK SPKEHFDFFP LTIDVEERMY AAGRIPGSFF RREGRPSTDA 100
ILTCRLIDRP LRPSFVSGLR NEIQVVVTVL SLDPKDLYDV LAINAASAST 150
QISGLPFSGP VGGVRVALID GQWVAFPTVE QLERAVFDMV VAGRKVGDDH 200
KDVAIMMVEA EATENVIELV AGGAGAPTET VVAEGLEAAK PFIAVLCDAQ 250
AALAGAAGKE TAEYPLFPDY GDDVYYSVAS VATEALSEAL TIAGKNERND 300
RTDEIKVEVL NRLAEQYAGR EKEIGAAYRS LTKKLVRQRI LTDHFRIDGR 350
GVTDIRALSA EVAVVPRAHG SALFERGETQ IMGVTTLDMV KMAQQIDSLG 400
PETSKRYMHH YNFPPYSTGE TGRVGSPKRR EIGHGALAER ALVPVLPSVE 450
EFPYAIRQVS EALGSNGSTS MGSVCASTLS LLNAGVPLKA PVAGIAMGLV 500
SDDIEIDGKT ERRFVTLTDI LGAEDAFGDM DFKCAGTKDF VTALQLDTKL 550
DGIPSQVLAG ALAQAKDARI TILEVMAEAI DTPDEMSPYA PRITTIKVPV 600
DKIGEVIGPK GKMINSITEE TGASISIEDD GTVFVGASNG EAAQAAIDKI 650
NAIANPQLPK VGERFLGTVV KTTDFGAFVS LLPGRDGLVH ISKLGRGKRI 700
NKVEDVAKVG DKLRVEIADI DNRGKISLVL VAEESETAAD APADAPVDAA 750
TTSS 754
Length:754
Mass (Da):80,173
Last modified:February 6, 2007 - v1
Checksum:i8CEF566CB7A92801
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13164.1.
RefSeqiWP_011779576.1. NC_008726.1.
YP_953170.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13164; ABM13164; Mvan_2350.
GeneIDi4648020.
KEGGimva:Mvan_2350.
PATRICi18182951. VBIMycVan31953_2402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13164.1 .
RefSeqi WP_011779576.1. NC_008726.1.
YP_953170.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T7L4.
SMRi A1T7L4. Positions 13-725.
ModBasei Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_2350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM13164 ; ABM13164 ; Mvan_2350 .
GeneIDi 4648020.
KEGGi mva:Mvan_2350.
PATRICi 18182951. VBIMycVan31953_2402.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-2364-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiPNP_MYCVP
AccessioniPrimary (citable) accession number: A1T7L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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