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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi435 – 442GTPUniRule annotation8
Nucleotide bindingi485 – 489GTPUniRule annotation5
Nucleotide bindingi539 – 542GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Mvan_2314
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000082861 – 930Translation initiation factor IF-2Add BLAST930

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2314.

Structurei

3D structure databases

ProteinModelPortaliA1T7H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini426 – 598tr-type GAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni435 – 442G1By similarity8
Regioni460 – 464G2By similarity5
Regioni485 – 488G3By similarity4
Regioni539 – 542G4By similarity4
Regioni575 – 577G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiGGTQGAF.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1T7H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES
60 70 80 90 100
YGGSKSDKTK AAPSGNGAAG ATVKPSAPQS RPGPKPGPPV AQQPAAPAAP
110 120 130 140 150
PAAPPAPPTP AAAPPSPAPA APAAATPAEP AAPSARPGPT PGPRPGPSAP
160 170 180 190 200
KPGAPKPAAR TPRVGNNPFS SQQPVERPAP RPQGPGGPRP GPGAGGPRPG
210 220 230 240 250
GGPRPGASPG SMPPRPQGAR PGGGPRPGGG PRPGGGPRPT PGGAGRPGGG
260 270 280 290 300
GGGGGNYRGG GAGGGAPAAG GGGFRGRPGG GGGGGRPGQR GGAAGAFGRP
310 320 330 340 350
GGAPKRGRKS KRAKRAEYEN MQAPVVGGVR LPHGNGETIR LARGASLSDF
360 370 380 390 400
AEKINANPAS LVQALFNLGE MVTATQSVGD ETLELLGGEM NYVVQVVSPE
410 420 430 440 450
DEDRELLESF DLTYGEDEGG EEDLEIRPPV VTVMGHVDHG KTRLLDTIRN
460 470 480 490 500
ATVREGEAGG ITQHIGAYQV TVDLDGTERP ITFIDTPGHE AFTAMRARGA
510 520 530 540 550
KATDIAILVV AADDGVMPQT VEAINHAQAA DVPIVVAVNK IDKEGADPAK
560 570 580 590 600
IRGQLTEYGL VPEEYGGDAM FVDISAKQGT NIEALLEAVI LTADASLDLR
610 620 630 640 650
ANPDMEAQGV AIEAHLDRGR GPVATVLIQR GTLRVGDSVV AGDAYGRVRR
660 670 680 690 700
MVDEHGEDVE EALPSRPVQV IGFTSVPGAG DNFLVVDEDR IARQIADRRS
710 720 730 740 750
ARKRNALAAR TRKRISLEDL DSALKETSQL NLILKGDNSG TVEALEEALL
760 770 780 790 800
GIQVDDEVEL RVIDRGVGGV TETNVNLASA SDAIIIGFNV RAEGKATELA
810 820 830 840 850
NREGVEIRYY SIIYQAIDEI ESALKGMLKP VYEEKELGRA EIRAIFRSSK
860 870 880 890 900
VGNIAGCLVQ SGIMRRNAKA RLLRDNVVVA ENLTISSLKR EKDDVTEVRD
910 920 930
GYECGLTLTY SDIKEGDVIE TYELVEKART
Length:930
Mass (Da):96,072
Last modified:February 6, 2007 - v1
Checksum:i9303DEFDD94516FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13128.1.

Genome annotation databases

EnsemblBacteriaiABM13128; ABM13128; Mvan_2314.
KEGGimva:Mvan_2314.
PATRICi18182875. VBIMycVan31953_2364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13128.1.

3D structure databases

ProteinModelPortaliA1T7H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350058.Mvan_2314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM13128; ABM13128; Mvan_2314.
KEGGimva:Mvan_2314.
PATRICi18182875. VBIMycVan31953_2364.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiGGTQGAF.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_MYCVP
AccessioniPrimary (citable) accession number: A1T7H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.