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A1T7H8

- IF2_MYCVP

UniProt

A1T7H8 - IF2_MYCVP

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Protein

Translation initiation factor IF-2

Gene
infB, Mvan_2314
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi435 – 4428GTP By similarity
Nucleotide bindingi485 – 4895GTP By similarity
Nucleotide bindingi539 – 5424GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-2328-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:Mvan_2314
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Translation initiation factor IF-2UniRule annotationPRO_1000008286Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2314.

Structurei

3D structure databases

ProteinModelPortaliA1T7H8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini426 – 598173tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni435 – 4428G1 By similarity
Regioni460 – 4645G2 By similarity
Regioni485 – 4884G3 By similarity
Regioni539 – 5424G4 By similarity
Regioni575 – 5773G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1T7H8-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES    50
YGGSKSDKTK AAPSGNGAAG ATVKPSAPQS RPGPKPGPPV AQQPAAPAAP 100
PAAPPAPPTP AAAPPSPAPA APAAATPAEP AAPSARPGPT PGPRPGPSAP 150
KPGAPKPAAR TPRVGNNPFS SQQPVERPAP RPQGPGGPRP GPGAGGPRPG 200
GGPRPGASPG SMPPRPQGAR PGGGPRPGGG PRPGGGPRPT PGGAGRPGGG 250
GGGGGNYRGG GAGGGAPAAG GGGFRGRPGG GGGGGRPGQR GGAAGAFGRP 300
GGAPKRGRKS KRAKRAEYEN MQAPVVGGVR LPHGNGETIR LARGASLSDF 350
AEKINANPAS LVQALFNLGE MVTATQSVGD ETLELLGGEM NYVVQVVSPE 400
DEDRELLESF DLTYGEDEGG EEDLEIRPPV VTVMGHVDHG KTRLLDTIRN 450
ATVREGEAGG ITQHIGAYQV TVDLDGTERP ITFIDTPGHE AFTAMRARGA 500
KATDIAILVV AADDGVMPQT VEAINHAQAA DVPIVVAVNK IDKEGADPAK 550
IRGQLTEYGL VPEEYGGDAM FVDISAKQGT NIEALLEAVI LTADASLDLR 600
ANPDMEAQGV AIEAHLDRGR GPVATVLIQR GTLRVGDSVV AGDAYGRVRR 650
MVDEHGEDVE EALPSRPVQV IGFTSVPGAG DNFLVVDEDR IARQIADRRS 700
ARKRNALAAR TRKRISLEDL DSALKETSQL NLILKGDNSG TVEALEEALL 750
GIQVDDEVEL RVIDRGVGGV TETNVNLASA SDAIIIGFNV RAEGKATELA 800
NREGVEIRYY SIIYQAIDEI ESALKGMLKP VYEEKELGRA EIRAIFRSSK 850
VGNIAGCLVQ SGIMRRNAKA RLLRDNVVVA ENLTISSLKR EKDDVTEVRD 900
GYECGLTLTY SDIKEGDVIE TYELVEKART 930
Length:930
Mass (Da):96,072
Last modified:February 6, 2007 - v1
Checksum:i9303DEFDD94516FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13128.1.
RefSeqiWP_011779540.1. NC_008726.1.
YP_953134.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13128; ABM13128; Mvan_2314.
GeneIDi4644349.
KEGGimva:Mvan_2314.
PATRICi18182875. VBIMycVan31953_2364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM13128.1 .
RefSeqi WP_011779540.1. NC_008726.1.
YP_953134.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T7H8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_2314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM13128 ; ABM13128 ; Mvan_2314 .
GeneIDi 4644349.
KEGGi mva:Mvan_2314.
PATRICi 18182875. VBIMycVan31953_2364.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-2328-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiIF2_MYCVP
AccessioniPrimary (citable) accession number: A1T7H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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