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A1T7H8 (IF2_MYCVP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Mvan_2314
OrganismMycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]
Taxonomic identifier350058 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length930 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 930930Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000008286

Regions

Nucleotide binding435 – 4428GTP By similarity
Nucleotide binding485 – 4895GTP By similarity
Nucleotide binding539 – 5424GTP By similarity
Region429 – 581153G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
A1T7H8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9303DEFDD94516FC

FASTA93096,072
        10         20         30         40         50         60 
MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES YGGSKSDKTK 

        70         80         90        100        110        120 
AAPSGNGAAG ATVKPSAPQS RPGPKPGPPV AQQPAAPAAP PAAPPAPPTP AAAPPSPAPA 

       130        140        150        160        170        180 
APAAATPAEP AAPSARPGPT PGPRPGPSAP KPGAPKPAAR TPRVGNNPFS SQQPVERPAP 

       190        200        210        220        230        240 
RPQGPGGPRP GPGAGGPRPG GGPRPGASPG SMPPRPQGAR PGGGPRPGGG PRPGGGPRPT 

       250        260        270        280        290        300 
PGGAGRPGGG GGGGGNYRGG GAGGGAPAAG GGGFRGRPGG GGGGGRPGQR GGAAGAFGRP 

       310        320        330        340        350        360 
GGAPKRGRKS KRAKRAEYEN MQAPVVGGVR LPHGNGETIR LARGASLSDF AEKINANPAS 

       370        380        390        400        410        420 
LVQALFNLGE MVTATQSVGD ETLELLGGEM NYVVQVVSPE DEDRELLESF DLTYGEDEGG 

       430        440        450        460        470        480 
EEDLEIRPPV VTVMGHVDHG KTRLLDTIRN ATVREGEAGG ITQHIGAYQV TVDLDGTERP 

       490        500        510        520        530        540 
ITFIDTPGHE AFTAMRARGA KATDIAILVV AADDGVMPQT VEAINHAQAA DVPIVVAVNK 

       550        560        570        580        590        600 
IDKEGADPAK IRGQLTEYGL VPEEYGGDAM FVDISAKQGT NIEALLEAVI LTADASLDLR 

       610        620        630        640        650        660 
ANPDMEAQGV AIEAHLDRGR GPVATVLIQR GTLRVGDSVV AGDAYGRVRR MVDEHGEDVE 

       670        680        690        700        710        720 
EALPSRPVQV IGFTSVPGAG DNFLVVDEDR IARQIADRRS ARKRNALAAR TRKRISLEDL 

       730        740        750        760        770        780 
DSALKETSQL NLILKGDNSG TVEALEEALL GIQVDDEVEL RVIDRGVGGV TETNVNLASA 

       790        800        810        820        830        840 
SDAIIIGFNV RAEGKATELA NREGVEIRYY SIIYQAIDEI ESALKGMLKP VYEEKELGRA 

       850        860        870        880        890        900 
EIRAIFRSSK VGNIAGCLVQ SGIMRRNAKA RLLRDNVVVA ENLTISSLKR EKDDVTEVRD 

       910        920        930 
GYECGLTLTY SDIKEGDVIE TYELVEKART 

« Hide

References

[1]"Complete sequence of Mycobacterium vanbaalenii PYR-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000511 Genomic DNA. Translation: ABM13128.1.
RefSeqYP_953134.1. NC_008726.1.

3D structure databases

ProteinModelPortalA1T7H8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING350058.Mvan_2314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM13128; ABM13128; Mvan_2314.
GeneID4644349.
KEGGmva:Mvan_2314.
PATRIC18182875. VBIMycVan31953_2364.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMANPDMDAQ.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycMVAN350058:GIWR-2328-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_MYCVP
AccessionPrimary (citable) accession number: A1T7H8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries