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A1T7H8

- IF2_MYCVP

UniProt

A1T7H8 - IF2_MYCVP

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi435 – 4428GTPUniRule annotation
    Nucleotide bindingi485 – 4895GTPUniRule annotation
    Nucleotide bindingi539 – 5424GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMVAN350058:GIWR-2328-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:Mvan_2314
    OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
    Taxonomic identifieri350058 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000009159: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 930930Translation initiation factor IF-2PRO_1000008286Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350058.Mvan_2314.

    Structurei

    3D structure databases

    ProteinModelPortaliA1T7H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini426 – 598173tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni435 – 4428G1By similarity
    Regioni460 – 4645G2By similarity
    Regioni485 – 4884G3By similarity
    Regioni539 – 5424G4By similarity
    Regioni575 – 5773G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiNPDMDAQ.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1T7H8-1 [UniParc]FASTAAdd to Basket

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    MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES    50
    YGGSKSDKTK AAPSGNGAAG ATVKPSAPQS RPGPKPGPPV AQQPAAPAAP 100
    PAAPPAPPTP AAAPPSPAPA APAAATPAEP AAPSARPGPT PGPRPGPSAP 150
    KPGAPKPAAR TPRVGNNPFS SQQPVERPAP RPQGPGGPRP GPGAGGPRPG 200
    GGPRPGASPG SMPPRPQGAR PGGGPRPGGG PRPGGGPRPT PGGAGRPGGG 250
    GGGGGNYRGG GAGGGAPAAG GGGFRGRPGG GGGGGRPGQR GGAAGAFGRP 300
    GGAPKRGRKS KRAKRAEYEN MQAPVVGGVR LPHGNGETIR LARGASLSDF 350
    AEKINANPAS LVQALFNLGE MVTATQSVGD ETLELLGGEM NYVVQVVSPE 400
    DEDRELLESF DLTYGEDEGG EEDLEIRPPV VTVMGHVDHG KTRLLDTIRN 450
    ATVREGEAGG ITQHIGAYQV TVDLDGTERP ITFIDTPGHE AFTAMRARGA 500
    KATDIAILVV AADDGVMPQT VEAINHAQAA DVPIVVAVNK IDKEGADPAK 550
    IRGQLTEYGL VPEEYGGDAM FVDISAKQGT NIEALLEAVI LTADASLDLR 600
    ANPDMEAQGV AIEAHLDRGR GPVATVLIQR GTLRVGDSVV AGDAYGRVRR 650
    MVDEHGEDVE EALPSRPVQV IGFTSVPGAG DNFLVVDEDR IARQIADRRS 700
    ARKRNALAAR TRKRISLEDL DSALKETSQL NLILKGDNSG TVEALEEALL 750
    GIQVDDEVEL RVIDRGVGGV TETNVNLASA SDAIIIGFNV RAEGKATELA 800
    NREGVEIRYY SIIYQAIDEI ESALKGMLKP VYEEKELGRA EIRAIFRSSK 850
    VGNIAGCLVQ SGIMRRNAKA RLLRDNVVVA ENLTISSLKR EKDDVTEVRD 900
    GYECGLTLTY SDIKEGDVIE TYELVEKART 930
    Length:930
    Mass (Da):96,072
    Last modified:February 6, 2007 - v1
    Checksum:i9303DEFDD94516FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM13128.1.
    RefSeqiWP_011779540.1. NC_008726.1.
    YP_953134.1. NC_008726.1.

    Genome annotation databases

    EnsemblBacteriaiABM13128; ABM13128; Mvan_2314.
    GeneIDi4644349.
    KEGGimva:Mvan_2314.
    PATRICi18182875. VBIMycVan31953_2364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000511 Genomic DNA. Translation: ABM13128.1 .
    RefSeqi WP_011779540.1. NC_008726.1.
    YP_953134.1. NC_008726.1.

    3D structure databases

    ProteinModelPortali A1T7H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350058.Mvan_2314.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM13128 ; ABM13128 ; Mvan_2314 .
    GeneIDi 4644349.
    KEGGi mva:Mvan_2314.
    PATRICi 18182875. VBIMycVan31953_2364.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi NPDMDAQ.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci MVAN350058:GIWR-2328-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 7251 / PYR-1.

    Entry informationi

    Entry nameiIF2_MYCVP
    AccessioniPrimary (citable) accession number: A1T7H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3