Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1T7H8

- IF2_MYCVP

UniProt

A1T7H8 - IF2_MYCVP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi435 – 4428GTPUniRule annotation
Nucleotide bindingi485 – 4895GTPUniRule annotation
Nucleotide bindingi539 – 5424GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-2328-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Mvan_2314
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Translation initiation factor IF-2PRO_1000008286Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2314.

Structurei

3D structure databases

ProteinModelPortaliA1T7H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini426 – 598173tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni435 – 4428G1By similarity
Regioni460 – 4645G2By similarity
Regioni485 – 4884G3By similarity
Regioni539 – 5424G4By similarity
Regioni575 – 5773G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1T7H8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES
60 70 80 90 100
YGGSKSDKTK AAPSGNGAAG ATVKPSAPQS RPGPKPGPPV AQQPAAPAAP
110 120 130 140 150
PAAPPAPPTP AAAPPSPAPA APAAATPAEP AAPSARPGPT PGPRPGPSAP
160 170 180 190 200
KPGAPKPAAR TPRVGNNPFS SQQPVERPAP RPQGPGGPRP GPGAGGPRPG
210 220 230 240 250
GGPRPGASPG SMPPRPQGAR PGGGPRPGGG PRPGGGPRPT PGGAGRPGGG
260 270 280 290 300
GGGGGNYRGG GAGGGAPAAG GGGFRGRPGG GGGGGRPGQR GGAAGAFGRP
310 320 330 340 350
GGAPKRGRKS KRAKRAEYEN MQAPVVGGVR LPHGNGETIR LARGASLSDF
360 370 380 390 400
AEKINANPAS LVQALFNLGE MVTATQSVGD ETLELLGGEM NYVVQVVSPE
410 420 430 440 450
DEDRELLESF DLTYGEDEGG EEDLEIRPPV VTVMGHVDHG KTRLLDTIRN
460 470 480 490 500
ATVREGEAGG ITQHIGAYQV TVDLDGTERP ITFIDTPGHE AFTAMRARGA
510 520 530 540 550
KATDIAILVV AADDGVMPQT VEAINHAQAA DVPIVVAVNK IDKEGADPAK
560 570 580 590 600
IRGQLTEYGL VPEEYGGDAM FVDISAKQGT NIEALLEAVI LTADASLDLR
610 620 630 640 650
ANPDMEAQGV AIEAHLDRGR GPVATVLIQR GTLRVGDSVV AGDAYGRVRR
660 670 680 690 700
MVDEHGEDVE EALPSRPVQV IGFTSVPGAG DNFLVVDEDR IARQIADRRS
710 720 730 740 750
ARKRNALAAR TRKRISLEDL DSALKETSQL NLILKGDNSG TVEALEEALL
760 770 780 790 800
GIQVDDEVEL RVIDRGVGGV TETNVNLASA SDAIIIGFNV RAEGKATELA
810 820 830 840 850
NREGVEIRYY SIIYQAIDEI ESALKGMLKP VYEEKELGRA EIRAIFRSSK
860 870 880 890 900
VGNIAGCLVQ SGIMRRNAKA RLLRDNVVVA ENLTISSLKR EKDDVTEVRD
910 920 930
GYECGLTLTY SDIKEGDVIE TYELVEKART
Length:930
Mass (Da):96,072
Last modified:February 6, 2007 - v1
Checksum:i9303DEFDD94516FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13128.1.
RefSeqiYP_953134.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM13128; ABM13128; Mvan_2314.
GeneIDi4644349.
KEGGimva:Mvan_2314.
PATRICi18182875. VBIMycVan31953_2364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA. Translation: ABM13128.1 .
RefSeqi YP_953134.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T7H8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_2314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM13128 ; ABM13128 ; Mvan_2314 .
GeneIDi 4644349.
KEGGi mva:Mvan_2314.
PATRICi 18182875. VBIMycVan31953_2364.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-2328-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiIF2_MYCVP
AccessioniPrimary (citable) accession number: A1T7H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3