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A1T7C4 (A1T7C4_MYCVP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:Mvan_2260
OrganismMycobacterium vanbaalenii (strain DSM 7251 / PYR-1) [Complete proteome] [HAMAP]
Taxonomic identifier350058 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding13 – 4230NADP By similarity HAMAP MF_00183

Sites

Metal binding1461Divalent metal cation By similarity HAMAP MF_00183
Metal binding1481Divalent metal cation By similarity HAMAP MF_00183
Metal binding2171Divalent metal cation By similarity HAMAP MF_00183
Binding site1231Substrate By similarity HAMAP MF_00183
Binding site1481Substrate By similarity HAMAP MF_00183
Binding site1721Substrate By similarity HAMAP MF_00183
Binding site1951Substrate By similarity HAMAP MF_00183
Binding site2171Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A1T7C4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 735D6F1BF211D74E

FASTA39040,410
        10         20         30         40         50         60 
MSETGAPLRV VILGSTGSIG TQALDVIAAN PDRFQVVGLA AGGGNTDLLA RQRAETGVTN 

        70         80         90        100        110        120 
IAVADEAAAT AVGGVTYSGP DAATRLVENT EADVVLNALV GALGLKPTLA ALATGARLAL 

       130        140        150        160        170        180 
ANKESLVAGG PLVQKAAAPG QIVPVDSEHS ALAQCLRGGT GDEVARLVLT ASGGPFHGWT 

       190        200        210        220        230        240 
ADRLEDVTPE QAAAHPTWSM GPMNTLNSAS LVNKGLELIE THLLFGVDYD RIDVVVHPQS 

       250        260        270        280        290        300 
IVHSMVTFTD GSTLAQASPP DMKLPIALAL GWPSRVPGAA PACDFTTASR WDFEPLDDEV 

       310        320        330        340        350        360 
FPAVALAREA GRGGGCLTAV YNAANEEAAE AFLNGRIRFP AIVRTVARVL RAADQWAAEP 

       370        380        390 
ATVDDVLDAQ DWARDRARRA VEQEPAGSRR

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References

[1]"Complete sequence of Mycobacterium vanbaalenii PYR-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.J., Miller C., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7251 / PYR-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000511 Genomic DNA. Translation: ABM13074.1.
RefSeqYP_953080.1. NC_008726.1.

3D structure databases

ProteinModelPortalA1T7C4.
SMRA1T7C4. Positions 8-381.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1T7C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000081783; EBMYCP00000079736; EBMYCG00000081778.
GeneID4649363.
GenomeReviewsGene locus Mvan_2260 in contig CP000511_GR.
KEGGmva:Mvan_2260.
PATRIC18182763. VBIMycVan31953_2308.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
GeneTreeEBGT00050000016490.
HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1T7C4_MYCVP
AccessionPrimary (citable) accession number: A1T7C4
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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