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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi312Magnesium or manganese 1UniRule annotation1
Metal bindingi324Magnesium or manganese 1UniRule annotation1
Metal bindingi324Magnesium or manganese 2UniRule annotation1
Metal bindingi326Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 233ATPUniRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:G1G7S-2167-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Mvan_2143
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003411371 – 367D-alanine--D-alanine ligaseAdd BLAST367

Proteomic databases

PRIDEiA1T708

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2143

Structurei

3D structure databases

ProteinModelPortaliA1T708
SMRiA1T708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 357ATP-graspUniRule annotationAdd BLAST208

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011593
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H06GK

Family and domain databases

HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1T708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARIRVAVV YGGRSSEHAI SCVSAGSILR NLDPQRFEVV PVGITPEGSW
60 70 80 90 100
VLTDGRPETL AITDGALPGV SGSSGTELAL AADPGRRGQL LSLGDAAGDV
110 120 130 140 150
LAAVDVVFPV LHGPYGEDGT IQGLLELAGV PYVGAGVLAS AAGMDKEFTK
160 170 180 190 200
KLLTAAGLPV GDHVVLRPRE ATVSLEDRER LGLPVFVKPS RGGSSIGVSR
210 220 230 240 250
VTAWDALPAA IELARRHDPK VIVEAAIPGR ELECGVLEFP DGHLEASTVG
260 270 280 290 300
EIRVAGVRGR EDGFYDFETK YLDDGAELDV PAKVDDAIAE AVRGLAIRAF
310 320 330 340 350
DAIDCQGLAR VDFFLTDAGP VINEINTMPG FTTISMYPRM WAASGIDYPT
360
LLATMVETAI ARGTGLR
Length:367
Mass (Da):38,482
Last modified:February 6, 2007 - v1
Checksum:i71A07FA31C1AD6FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM12958.1
RefSeqiWP_011779372.1, NC_008726.1

Genome annotation databases

EnsemblBacteriaiABM12958; ABM12958; Mvan_2143
KEGGimva:Mvan_2143

Similar proteinsi

Entry informationi

Entry nameiDDL_MYCVP
AccessioniPrimary (citable) accession number: A1T708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 6, 2007
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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