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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mvan_2140
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000009159 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987011 – 2132-phospho-L-lactate guanylyltransferaseAdd BLAST213

Proteomic databases

PRIDEiA1T705

Interactioni

Protein-protein interaction databases

STRINGi350058.Mvan_2140

Structurei

3D structure databases

ProteinModelPortaliA1T705
SMRiA1T705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

A1T705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSHADVGL VIAVKRLTAA KTRLAPMFSA RTREDVVLAM LVDTITAAIA
60 70 80 90 100
VPALRSVLVV TPDEDAADAA RQLGALVLPD PTPQGHHDPL NNALTAAEVV
110 120 130 140 150
ARRENTNVVA LQGDLPALRT VELAEAIGAA RAHARSFVTD RHGTGTSALF
160 170 180 190 200
SFGAPLDPHF GLDSAQRHRR SGAVELTGDW PGLRSDIDTP DDVLALNDLG
210
VGPATARAIA RAQ
Length:213
Mass (Da):22,317
Last modified:February 6, 2007 - v1
Checksum:i8017FF1C29369089
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM12955.1

Genome annotation databases

EnsemblBacteriaiABM12955; ABM12955; Mvan_2140
KEGGimva:Mvan_2140

Similar proteinsi

Entry informationi

Entry nameiCOFC_MYCVP
AccessioniPrimary (citable) accession number: A1T705
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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