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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Mvan_2133
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000009159 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000019251 – 495Glutamate--tRNA ligaseAdd BLAST495

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_2133

Structurei

3D structure databases

ProteinModelPortaliA1T6Z8
SMRiA1T6Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 23"HIGH" regionUniRule annotationAdd BLAST11
Motifi257 – 261"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A1T6Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSDVVRVR FCPSPTGTPH VGLIRTALFN WAYARHTGGT FVFRIEDTDS
60 70 80 90 100
ARDSEDSYLA LLDALRWLGM DWDEGPEIGG PYGPYRQSQR LDIYTDVIER
110 120 130 140 150
LLAAGEAYEA FSTAEEVEAR HIAAGRNPKL GYDNYDRDLT EEQRAAFRAE
160 170 180 190 200
GRRPVVRLRM PDTDLTWVDL VRGETTFPAG SVPDFALTRG NGEPLYPLVN
210 220 230 240 250
PVDDALMKIT HVLRGEDLLP STPRQLALYG ALIRIGVADT TPQFAHLPSV
260 270 280 290 300
LGEGNKKLSK RDPQSNLFLH RDRGFIPEGL LNYLALLGWS IADDHDIFSL
310 320 330 340 350
EEMVAAFDVA DVNSSPARFD QKKADALNAE HIRLLDEAEF ARRLGAYFAT
360 370 380 390 400
HGHRTGLDDA QFAEAARLVQ TRIVVLGDAW ELLKFLDDAS FTLDEKSAAK
410 420 430 440 450
ELKAEAVPVL GAALEALRGV EAWDTAAIEE ALKGALIDRL ELKPRKAFGP
460 470 480 490
VRVAATGSSV SPPLFESLEL LGRDRSLARL QAGRDHAAAA AAPQG
Length:495
Mass (Da):54,424
Last modified:February 6, 2007 - v1
Checksum:i13985DC63657CF66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000511 Genomic DNA Translation: ABM12948.1

Genome annotation databases

EnsemblBacteriaiABM12948; ABM12948; Mvan_2133
KEGGimva:Mvan_2133

Similar proteinsi

Entry informationi

Entry nameiSYE_MYCVP
AccessioniPrimary (citable) accession number: A1T6Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health