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A1T6Z8

- SYE_MYCVP

UniProt

A1T6Z8 - SYE_MYCVP

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Protein

Glutamate--tRNA ligase

Gene
gltX, Mvan_2133
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei260 – 2601ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMVAN350058:GIWR-2145-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:Mvan_2133
OrganismiMycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Taxonomic identifieri350058 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000009159: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Glutamate--tRNA ligaseUniRule annotationPRO_1000001925Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi350058.Mvan_2133.

Structurei

3D structure databases

ProteinModelPortaliA1T6Z8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi13 – 2311"HIGH" regionUniRule annotationAdd
BLAST
Motifi257 – 2615"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiPEGMLNY.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A1T6Z8-1 [UniParc]FASTAAdd to Basket

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MTTSDVVRVR FCPSPTGTPH VGLIRTALFN WAYARHTGGT FVFRIEDTDS    50
ARDSEDSYLA LLDALRWLGM DWDEGPEIGG PYGPYRQSQR LDIYTDVIER 100
LLAAGEAYEA FSTAEEVEAR HIAAGRNPKL GYDNYDRDLT EEQRAAFRAE 150
GRRPVVRLRM PDTDLTWVDL VRGETTFPAG SVPDFALTRG NGEPLYPLVN 200
PVDDALMKIT HVLRGEDLLP STPRQLALYG ALIRIGVADT TPQFAHLPSV 250
LGEGNKKLSK RDPQSNLFLH RDRGFIPEGL LNYLALLGWS IADDHDIFSL 300
EEMVAAFDVA DVNSSPARFD QKKADALNAE HIRLLDEAEF ARRLGAYFAT 350
HGHRTGLDDA QFAEAARLVQ TRIVVLGDAW ELLKFLDDAS FTLDEKSAAK 400
ELKAEAVPVL GAALEALRGV EAWDTAAIEE ALKGALIDRL ELKPRKAFGP 450
VRVAATGSSV SPPLFESLEL LGRDRSLARL QAGRDHAAAA AAPQG 495
Length:495
Mass (Da):54,424
Last modified:February 6, 2007 - v1
Checksum:i13985DC63657CF66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM12948.1.
RefSeqiYP_952954.1. NC_008726.1.

Genome annotation databases

EnsemblBacteriaiABM12948; ABM12948; Mvan_2133.
GeneIDi4648802.
KEGGimva:Mvan_2133.
PATRICi18182497. VBIMycVan31953_2177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000511 Genomic DNA. Translation: ABM12948.1 .
RefSeqi YP_952954.1. NC_008726.1.

3D structure databases

ProteinModelPortali A1T6Z8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350058.Mvan_2133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM12948 ; ABM12948 ; Mvan_2133 .
GeneIDi 4648802.
KEGGi mva:Mvan_2133.
PATRICi 18182497. VBIMycVan31953_2177.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi PEGMLNY.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci MVAN350058:GIWR-2145-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 7251 / PYR-1.

Entry informationi

Entry nameiSYE_MYCVP
AccessioniPrimary (citable) accession number: A1T6Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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