ID   A1T6S5_MYCVP            Unreviewed;       521 AA.
AC   A1T6S5;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Metal dependent phosphohydrolase {ECO:0000313|EMBL:ABM12875.1};
GN   OrderedLocusNames=Mvan_2058 {ECO:0000313|EMBL:ABM12875.1};
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350058 {ECO:0000313|EMBL:ABM12875.1, ECO:0000313|Proteomes:UP000009159};
RN   [1] {ECO:0000313|EMBL:ABM12875.1, ECO:0000313|Proteomes:UP000009159}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC   PYR-1 {ECO:0000313|Proteomes:UP000009159};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000511; ABM12875.1; -; Genomic_DNA.
DR   RefSeq; WP_011779291.1; NZ_JACKSD010000322.1.
DR   AlphaFoldDB; A1T6S5; -.
DR   STRING; 350058.Mvan_2058; -.
DR   KEGG; mva:Mvan_2058; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_040286_1_0_11; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF13487; HD_5; 2.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 2.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51832; HD_GYP; 2.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Hydrolase {ECO:0000313|EMBL:ABM12875.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009159}.
FT   DOMAIN          10..244
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          260..456
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          282..397
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          451..516
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   521 AA;  55463 MW;  EF3AB7B7538E39E3 CRC64;
     MAPPAEHPAR SPSRAELLAA LSIAIDLGLG QPAEHMLRSA VIATRIAERL GLDRPQRDCC
     YYTALIMWIG CHADSHEYAH WFGDDIAVRH DSYLVDWTGL PYLRFLMANT GRGQPLLHRL
     SLMATLLADA RGQISQLIHS HCASAGMLAD RLGVSAEVQS ALGSTFERYD GGGLPGGVGG
     DDIPLPMRVA QLADMVEVHH RAYGVDGAVA MARSRRGGQF DPRVVDAFTA DAVTVLSVPA
     PGDAWTVALR EAPDYGERLH GAELDALLVA LGDFVDLKCP FTLGHSRAVA ELAAGAAAVV
     GLDADTVTVV RRAGHLHDLG RIGVSNQIWS KPSSLTAREL ERVRLHPYLT VRILSQVGGL
     DAVAQVAGNH HEYLDGSGYP RGLPAAALSL PDRLLAAAVA YQSALEPRPY RDPLPATSAA
     ARLRERVREG RLDEVAVEAV LQAAGHRARG HSPRPGGLTP REIEVLCLVA RGASNKEIAA
     TLGISGKTAR NHVERTYAKI GATNRIGASM FALNHGLVAP A
//